Document Detail


Sublingual nitroglycerin in the treatment of left ventricular failure and pulmonary edema.
MedLine Citation:
PMID:  823029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 15 patients with left heart failure due to coronary heart disease (10 acute and 5 old infarcts) the enddiastolic pressures in the pulmonary artery (left ventricular filling pressure) were elevated to 25 +/- 8 mm Hg and signs of pulmonary congestion were present. After nitroglycerin sublingually (0.8-1.6 mg) the left ventricular filling pressure fell to 17 +/- 8 mm Hg and caridac output tended to increase. Mean arterial pressure did not change significantly. In 6 patients with pulmonary edema, clinically an impressive improvement was observed within 5-15 min after administration of the drug. In 1 case the left ventricular filling pressure decreased from 50 to 27 mm Hg within 5 min. In left heart failure, especially in the presence of pulmonary edema, sublingual nitroglycerin is a potent drug with a favorable influence on hemodynamic and clinical parameters.
Authors:
W D Bussmann; M Kaltenbach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cardiology     Volume:  4     ISSN:  0301-4711     ISO Abbreviation:  Eur J Cardiol     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404054     Medline TA:  Eur J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Disease / complications
Depression, Chemical
Heart Failure / drug therapy*,  etiology
Heart Ventricles
Humans
Nitroglycerin / administration & dosage,  pharmacology,  therapeutic use*
Pulmonary Artery / physiology
Pulmonary Edema / drug therapy*
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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