Document Detail

Sublingual nitroglycerin in the treatment of left ventricular failure and pulmonary edema.
MedLine Citation:
PMID:  823029     Owner:  NLM     Status:  MEDLINE    
In 15 patients with left heart failure due to coronary heart disease (10 acute and 5 old infarcts) the enddiastolic pressures in the pulmonary artery (left ventricular filling pressure) were elevated to 25 +/- 8 mm Hg and signs of pulmonary congestion were present. After nitroglycerin sublingually (0.8-1.6 mg) the left ventricular filling pressure fell to 17 +/- 8 mm Hg and caridac output tended to increase. Mean arterial pressure did not change significantly. In 6 patients with pulmonary edema, clinically an impressive improvement was observed within 5-15 min after administration of the drug. In 1 case the left ventricular filling pressure decreased from 50 to 27 mm Hg within 5 min. In left heart failure, especially in the presence of pulmonary edema, sublingual nitroglycerin is a potent drug with a favorable influence on hemodynamic and clinical parameters.
W D Bussmann; M Kaltenbach
Related Documents :
3297489 - Thromboxane synthesis inhibition reverses group b streptococcus-induced pulmonary hyper...
7102509 - Effects of acute incremental volume overload on cardiac chamber size, function, and the...
17894029 - Pulmonary blood volume in rheumatic heart disease and its alteration by isoproterenol.
16147559 - Ascites in poultry: recent investigations.
8088349 - Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the pu...
11191719 - Suppressive effect of sarpogrelate hydrochloride on respiratory failure and right ventr...
2973759 - Atrial natriuretic factor may mediate the renal effects of peep ventilation.
22627959 - Re-expansion pulmonary edema in a patient with total pneumothorax: a hazardous outcome.
22801399 - Increased vascular tone due to sympathovagal imbalance in normotensive and prehypertens...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cardiology     Volume:  4     ISSN:  0301-4711     ISO Abbreviation:  Eur J Cardiol     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404054     Medline TA:  Eur J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Disease / complications
Depression, Chemical
Heart Failure / drug therapy*,  etiology
Heart Ventricles
Nitroglycerin / administration & dosage,  pharmacology,  therapeutic use*
Pulmonary Artery / physiology
Pulmonary Edema / drug therapy*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Litholytic agents with bacteriostatic properties in conservative treatment of urolithiasis.
Next Document:  Comparison of the pharmacokinetics of glipizide and glibenclamide in man.