Document Detail

Sublingual nifedipine compared with intravenous hydrallazine in the acute treatment of severe hypertension in pregnancy: potential for use in rural practice.
MedLine Citation:
PMID:  8624887     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purposes of this study were to compare the efficacy of sublingual nifedipine with intravenous hydrallazine in the control of acute hypertension of pregnancy and to make a preliminary assessment whether sublingual nifedipine could be recommended for use by midwives faced with severe hypertension in pregnancy in a rural setting. METHODS: Subjects were 200 consecutive patients admitted to Kuala Tereng-ganu General Hospital, Malaysia with severe hypertension in pregnancy between August 1989 and June 1990. Admission criteria were an ongoing viable pregnancy more than 28 weeks and diastolic blood pressure (DBP) more than 120 mmHg. The patients were randomly divided into 2 groups. In group I, sublingual nifedipine 5 mg was administered and repeated after 15 minutes if DBP > 120 mmHg; and in group II hydrallazine 5 mg was intravenously injected and repeated after 15 minutes if DBP > 120 mmHg. Both groups were put on hydrallazine infusion if DBP > 120 mmHg after 30 minutes. The Chi-square test was used for analysis with significance at p < 0.05. RESULTS: There was no statistical difference in the efficacy of therapy for decreasing blood pressure between the 2 groups. The groups were comparable by age, parity, gestational age at presentation, birth weight of infants, incidence of postpartum haemorrhage and fetal distress. Caesarian section rates were similar. In the observational studies on nurses administering the drugs, no significant difficulties were observed. CONCLUSION: Sublingual nifedipine was comparable to IV hydrallazine in the treatment of acute hypertension of pregnancy. Nurses were able to administer lingual nifedipine without difficulty.
R Jegasothy; S Paranthaman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  22     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-06-21     Completed Date:  1996-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Seremban Hospital, Negeri Sembilan, Malaysia.
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MeSH Terms
Administration, Sublingual
Antihypertensive Agents / administration & dosage*
Calcium Channel Blockers / administration & dosage*
Hydralazine / administration & dosage*
Hypertension / drug therapy*
Infusions, Intravenous
Injections, Intravenous
Nifedipine / administration & dosage*
Pregnancy Complications, Cardiovascular / drug therapy*
Rural Population
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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