| Sublingual nifedipine compared with intravenous hydrallazine in the acute treatment of severe hypertension in pregnancy: potential for use in rural practice. | |
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MedLine Citation:
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PMID: 8624887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The purposes of this study were to compare the efficacy of sublingual nifedipine with intravenous hydrallazine in the control of acute hypertension of pregnancy and to make a preliminary assessment whether sublingual nifedipine could be recommended for use by midwives faced with severe hypertension in pregnancy in a rural setting. METHODS: Subjects were 200 consecutive patients admitted to Kuala Tereng-ganu General Hospital, Malaysia with severe hypertension in pregnancy between August 1989 and June 1990. Admission criteria were an ongoing viable pregnancy more than 28 weeks and diastolic blood pressure (DBP) more than 120 mmHg. The patients were randomly divided into 2 groups. In group I, sublingual nifedipine 5 mg was administered and repeated after 15 minutes if DBP > 120 mmHg; and in group II hydrallazine 5 mg was intravenously injected and repeated after 15 minutes if DBP > 120 mmHg. Both groups were put on hydrallazine infusion if DBP > 120 mmHg after 30 minutes. The Chi-square test was used for analysis with significance at p < 0.05. RESULTS: There was no statistical difference in the efficacy of therapy for decreasing blood pressure between the 2 groups. The groups were comparable by age, parity, gestational age at presentation, birth weight of infants, incidence of postpartum haemorrhage and fetal distress. Caesarian section rates were similar. In the observational studies on nurses administering the drugs, no significant difficulties were observed. CONCLUSION: Sublingual nifedipine was comparable to IV hydrallazine in the treatment of acute hypertension of pregnancy. Nurses were able to administer lingual nifedipine without difficulty. |
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Authors:
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R Jegasothy; S Paranthaman |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 22 ISSN: 1341-8076 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-06-21 Completed Date: 1996-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: JAPAN |
Other Details:
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Languages: eng Pagination: 21-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Seremban Hospital, Negeri Sembilan, Malaysia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Sublingual Antihypertensive Agents / administration & dosage* Calcium Channel Blockers / administration & dosage* Female Humans Hydralazine / administration & dosage* Hypertension / drug therapy* Infusions, Intravenous Injections, Intravenous Nifedipine / administration & dosage* Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* Rural Population |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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