| Sublingual desensitization in patients with wasp venom allergy: preliminary results. | |
| | |
MedLine Citation:
|
PMID: 18831935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this paper is to assess in an open prospective pilot case-control study the tolerability, safety and efficacy of an ultra-rush sublingual immunotherapy (SLIT) protocol with Vespula venom in wasp allergic patients compared to subcutaneous immunotherapy (SCIT). Forty-one wasp allergic patients were treated with sublingual (SLIT group) or subcutaneous (SCIT group) ultrarush immunotherapy with Vespula venom extract. All patients underwent skin tests and serum specific IgE and IgG4 detection before enrollment and after 6, 12 and 24 months of immunotherapy. The SLIT group consisted of 21 (6 females and 15 males) patients who received increasing doses of Vespula venom (Aquagen, ALK-Abellò) until the final dose of 30 drops of extract in 3 hours, containing 100,000 SQ-U/ml. The maintenance dose was of 10 drops of pure venom extract 3 times a week, for a total dose of 100,000 SQ-U weekly (corresponding to 100 microgram of venom extract). The SCIT group consisted of 20 patients (16 males and 4 females) who were treated with subcutaneous ultrarush immunotherapy with Vespula venom extract (Pharmalgen, Alk-Abellò). Patients received 101.1 microgram of Vespula venom in 3 hours and were treated with 100 microgram of wasp venom monthly. During the ultrarush sublingual treatment 2 patients (9.5%) experienced mild side-effects. Specific IgE and specific IgG to wasp venom did not show any significant modification. Four patients were field-stung by a wasp during the treatment (for a total of 6 stings). Two patients (3 stings), with a previous clinical history of a grade III and IV reaction, did not experience any reaction. One patient, with a previous grade II reaction, showed a large local reaction. The fourth patient, with a previous grade III reaction, was re-stung twice (after 12 and 24 months) with two systemic reactions (SR) (mild throat constriction). During the ultrarush SCIT phase, 3 (15%) patients experienced side-effects: 2 of them showed a large local reaction and 1 had headache and stomach ache. Specific IgE showed a significant (P = 0.001) increase after 6 months of treatment and then returned to baseline levels while specific IgG showed a significant (P = 0.001) increase after 6, 12 and 24 months in comparison with baseline. Nine patients were field-stung during the treatment: 8 of them experienced large local reactions; one patient (11%) experienced an SR (dizziness). Our results, even if in a small number of patients, suggest that in patients with Hymenoptera sting allergy SLIT could be efficacious with a good tolerability profile when compared to SCIT. Larger studies are needed to assess efficacy, safety and tolerability profile of wasp venom SLIT. |
| | |
Authors:
|
G Patriarca; E Nucera; C Roncallo; A Aruanno; C Lombardo; M Decinti; L Pascolini; M Milani; A Buonomo; D Schiavino |
Related Documents
:
|
22155755 - Induction and maintenance therapy with infliximab for children with moderate-to-severe ... 9726385 - Short-term low-dose pantoprazole-based triple therapy for cure of helicobacter pylori i... 22008445 - Initial and programmed combination therapy with oral drugs for severe idiopathic pulmon... 17295875 - Cytochrome p450 2c19 polymorphism influences the preventive effect of lansoprazole on t... 2509355 - Nutrition and inflammatory bowel disease. 9272535 - Use of single lead vdd pacing in children. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of immunopathology and pharmacology Volume: 21 ISSN: 0394-6320 ISO Abbreviation: Int J Immunopathol Pharmacol Publication Date: 2008 Jul-Sep |
Date Detail:
|
Created Date: 2008-10-03 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8911335 Medline TA: Int J Immunopathol Pharmacol Country: Italy |
Other Details:
|
Languages: eng Pagination: 669-77 Citation Subset: IM |
Affiliation:
|
Department of Allergology, Catholic University, Rome, Italy. allergologia@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Sublingual Adolescent Adult Aged Case-Control Studies Desensitization, Immunologic* Female Humans Hypersensitivity, Immediate / therapy* Insect Bites and Stings / immunology Male Middle Aged Pilot Projects Prospective Studies Wasp Venoms / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Wasp Venoms |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antibodies to carbonic anhydrase in patients with connective tissue diseases: relationship with lung...
Next Document: Comparison of thermal infrared and laser doppler imaging in the assessment of cutaneous tissue perfu...