Document Detail


Sublethal effects of subacute exposure to RDX (1,3,5-trinitro-1,3,5-triazine) in the northern bobwhite (Colinus virginianus).
MedLine Citation:
PMID:  19173548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Northern bobwhite (Colinus virginianus) were orally exposed via gavage to 0, 0.5, 3, 8, 12, or 17 mg/kg of RDX (1,3,5-trinitro-1,3,5-triazine) in corn oil daily for 14 d to evaluate sublethal effects of this explosive in birds. Mortality occurred at a rates of 100, 67, and 25% for the 17, 12, and 8 mg/kg/d dose groups, respectively. Death was preceded by clonic and tonic convulsions and weight loss caused by gastrointestinal effects. Increases in serum globulin and total leukocytes were observed in the two highest-dose groups. Degeneration of testicular and splenic tissue also was observed. The no-observed-adverse-effects and lowest-observed-adverse-effects levels were determined as 3.0 and 8.0 mg/kg/d, respectively.
Authors:
Michael J Quinn; Matthew A Bazar; Craig A McFarland; Edward J Perkins; Kurt A Gust; Mark S Johnson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  28     ISSN:  0730-7268     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1266-70     Citation Subset:  IM    
Affiliation:
U.S. Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21010, USA. michael.james.quinn@us.army.mil
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MeSH Terms
Descriptor/Qualifier:
Animals
Colinus*
Dose-Response Relationship, Drug
Explosive Agents / pharmacokinetics,  toxicity*
No-Observed-Adverse-Effect Level
Soil Pollutants / pharmacokinetics,  toxicity*
Tissue Distribution
Triazines / pharmacokinetics,  toxicity*
Water Pollutants, Chemical / pharmacokinetics,  toxicity*
Chemical
Reg. No./Substance:
0/Explosive Agents; 0/Soil Pollutants; 0/Triazines; 0/Water Pollutants, Chemical; 121-82-4/cyclonite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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