Document Detail

Subjects with intellectual disability and familial need for full-time special education show regional brain alterations: a voxel-based morphometry study.
MedLine Citation:
PMID:  19531975     Owner:  NLM     Status:  MEDLINE    
Subjects attending full-time special education (SE) often have multifactorial background for their cognitive impairment, and brain MRI may show nonspecific changes. As voxel-based morphometry reveals regional volume differences, we applied this method to 119 subjects with cognitive impairments and familial need for full-time SE--graded into three levels from specific disorders of cognitive processes (level 1) to intellectual disability (IQ <70; level 3)--and to 43 age-matched controls attending mainstream education (level 0). Subjects in SE groups had smaller global brain white matter (WM), cerebrospinal fluid, and total brain volume than controls. Compared with controls, subjects with intellectual disabilities in SE level 3 showed greater regional gray matter volumes bilaterally in the ventral and dorsal anterior cingulate cortex and smaller regional gray matter volumes in the left thalamus and cerebellar hemisphere. Further, they had greater WM volume in the left frontoparietal region and smaller WM volumes in the posterior limbs of the internal capsules. Subjects in SE level 1 and 2 groups showed the same tendency, but the results were nonsignificant. In conclusion, compared with controls, subjects with intellectual disabilities showed in voxel-based morphometry analysis several regional brain alterations.
Minna K Mannerkoski; Hannu J Heiskala; Koen Van Leemput; Laura E Aberg; Raili Raininko; Janne Hämäläinen; Taina H Autti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  66     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  306-11     Citation Subset:  IM    
Department of Gynecology and Pediatrics, Helsinki University Central Hospital, 00290 Helsinki, Finland.
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MeSH Terms
Brain* / anatomy & histology,  pathology,  physiology
Brain Mapping / methods*
Child, Preschool
Cognition Disorders* / pathology,  physiopathology
Education, Special*
Image Processing, Computer-Assisted / methods
Intelligence / physiology
Magnetic Resonance Imaging / methods
Neuropsychological Tests
Psychiatric Status Rating Scales
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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