Document Detail

Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: a preliminary study.
MedLine Citation:
PMID:  17320313     Owner:  NLM     Status:  MEDLINE    
We examined subjective responses to smoking the first cigarette of the day and investigated how these responses related to smoking cessation treatment outcome. Data from participants (N=207) in a clinical trial of message framing for smoking cessation with bupropion, obtained prior to the targeted quit day, were used to examine indices of craving, withdrawal, and affect before and after smoking the first cigarette of the day. After smoking the initial cigarette, craving, withdrawal symptoms, and negative affect were lessened, and positive affect increased. Greater decreases in craving as measured by the questionnaire on smoking urges-brief (QSU-Brief) predicted relapse at the end of treatment (6 weeks) and at the 3-month follow-up time point. These associations do not appear to be mediated by established measures of dependence. Thus, this preliminary study provides evidence that there are significant changes in craving, withdrawal, and affect related to smoking the first cigarette of the day, with the largest of these changes observed for craving. Moreover, changes in tobacco craving in response to the first cigarette of the day may be a novel predictor of smoking relapse that should be tested in future studies.
Benjamin A Toll; Ty S Schepis; Stephanie S O'Malley; Sherry A McKee; Suchitra Krishnan-Sarin
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2007-02-22
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  89     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-08-17     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  302-5     Citation Subset:  IM    
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MeSH Terms
Affect* / drug effects
Antidepressive Agents, Second-Generation / therapeutic use*
Behavior Therapy*
Bupropion / therapeutic use*
Circadian Rhythm
Delayed-Action Preparations
Middle Aged
Nicotine / adverse effects
Outcome Assessment (Health Care)
Recurrence / prevention & control
Smoking / psychology*
Smoking Cessation / psychology*
Substance Withdrawal Syndrome / diagnosis,  psychology
Tobacco Use Disorder / psychology,  rehabilitation*
Grant Support
K05 AA 914715/AA/NIAAA NIH HHS; K05 AA014715/AA/NIAAA NIH HHS; K05 AA014715-04/AA/NIAAA NIH HHS; K12 DA 00167/DA/NIDA NIH HHS; K12 DA000167-14/DA/NIDA NIH HHS; P50 AA 15632/AA/NIAAA NIH HHS; P50 AA015632/AA/NIAAA NIH HHS; P50 AA015632-08/AA/NIAAA NIH HHS; P50 DA 13334/DA/NIDA NIH HHS; P50 DA013334/DA/NIDA NIH HHS; P50 DA013334-05/DA/NIDA NIH HHS; T32 DA 007238/DA/NIDA NIH HHS; T32 DA007238/DA/NIDA NIH HHS; T32 DA007238-16/DA/NIDA NIH HHS
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Delayed-Action Preparations; 01ZG3TPX31/Bupropion; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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