Document Detail

Subjective and neurovegetative changes in healthy volunteers and panic patients performing simulated public speaking.
MedLine Citation:
PMID:  15961294     Owner:  NLM     Status:  MEDLINE    
Drug-free symptomatic panic patients, drug-treated nonsymptomatic patients and healthy controls were submitted to simulated public speaking. Subjective anxiety, cognitive impairment and discomfort measured by the visual analog mood scale as well as skin conductance level were higher in symptomatic patients than in controls at the beginning of the experimental session, nonsymptomatic patients lying in between. Subjective sedation, spontaneous fluctuations of skin conductance, heart rate and blood pressure were similar in the three groups. Preparation and performance of speech decreased sedation while increasing anxiety, cognitive impairment, level and fluctuations of skin conductance, heart rate and blood pressure. Anxiety, cognitive impairment and conductance level were less increased in symptomatic patients than in controls. Electrodermal activity, but not cardiovascular measures of sympathetic arousal correlated with anticipatory anxiety. Chronic treatment with serotonin uptake inhibitors attenuated the differences between panic patients and controls, supporting the participation of serotonin in panic disorder.
Alexandre C B V Parente; Cybele Garcia-Leal; Cristina M Del-Ben; Francisco S Guimarães; Frederico G Graeff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-14
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  15     ISSN:  0924-977X     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  663-71     Citation Subset:  IM    
Department of Neurology, Psychiatry and Medical Psychology, Medical School of Ribeirão Preto, University of São Paulo, FMRP-USP, Av. 9 de Julho 980, 14025-000, Ribeirão Preto, SP, Brazil.
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MeSH Terms
Anxiety / metabolism,  physiopathology*,  psychology*
Blood Pressure / physiology
Galvanic Skin Response / physiology
Heart Rate / physiology
Hydrocortisone / blood*
Panic Disorder / drug therapy,  psychology*
Psychiatric Status Rating Scales
Serotonin Uptake Inhibitors / therapeutic use
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 50-23-7/Hydrocortisone

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