Document Detail

Subjective health status in Norwegian patients with Addison's disease.
MedLine Citation:
PMID:  12030907     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Many patients with Addison's disease have complaints that might be related to the disease or to its treatment. However, only a few studies have addressed the subjective health status of patients with adrenocortical failure. The aim of the present study was to assess the subjective health status with special emphasis on fatigue among patients with Addison's disease. SUBJECTS, DESIGN AND MEASUREMENT: In a postal survey, 79 patients with confirmed primary adrenal failure (Addison's disease) completed the Short Form 36 (SF-36) and the Fatigue questionnaires. The subjective health status in Addison's disease was compared with normative data from the general population. RESULTS: General health and vitality perception were most consistently impaired in the patients with Addison's disease. The scores on physical functioning and role-physical were low in women. Social functioning and role-emotional scores were also lower than normal in the female patients, but this was confined to the patients with autoimmune polyendocrine syndromes. Patients with autoimmune polyendocrine syndromes tended to have lower scores than patients with solitary Addison's disease. The level of fatigue was higher than normal for both men and women. Working disability at ages 18-67 years was 26%, compared with 10% in the corresponding general Norwegian population. The high working disability increased with age and was higher in subgroups with concomitant endocrine diseases. Most subjective health parameters were lower among the disabled compared to the patients in work. CONCLUSIONS: Patients with Addison's disease under replacement therapy with cortisone acetate and fludrocortisone have reduced general health perception and vitality, and increased fatigue. Female patients reported reduced physical function, which might be due to adrenal androgen depletion. Mental health seems more influenced by concomitant endocrine diseases, but mental fatigue might be a specific feature in adrenal failure. The patient population is heterogeneous, with normal findings in a substantial proportion but markedly reduced subjective health status and working ability in many others. Thus, there might be potential for further refinement of replacement therapy.
Kristian Løvås; Jon Håvard Loge; Eystein S Husebye
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  56     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-28     Completed Date:  2002-07-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  581-8     Citation Subset:  IM    
Division of Endocrinology, Institute of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway.
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MeSH Terms
Addison Disease / complications*,  drug therapy
Case-Control Studies
Cortisone / analogs & derivatives*,  therapeutic use
Disability Evaluation
Fatigue / drug therapy,  etiology*
Fludrocortisone / therapeutic use
Glucocorticoids / therapeutic use
Health Status*
Hormone Replacement Therapy
Middle Aged
Sex Factors
Social Isolation
Reg. No./Substance:
0/Glucocorticoids; 127-31-1/Fludrocortisone; 50-04-4/cortisone acetate; 53-06-5/Cortisone
Comment In:
Clin Endocrinol (Oxf). 2002 May;56(5):573-4   [PMID:  12030905 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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