Document Detail

Subjective concomitants of motion sickness: quantifying rotation-induced illness in squirrel monkeys.
MedLine Citation:
PMID:  3120118     Owner:  NLM     Status:  MEDLINE    
It has been suggested by numerous researchers that the development of conditioned food aversion (CFA) in experimental animals represents the presence of a subjective state of illness. Squirrel monkeys with proven susceptibility to rotation-induced vomiting were given surgical bilateral labyrinthectomies, a procedure known to abolish signs and symptoms of motion sickness in human beings. Postoperatively, labyrinthectomized monkeys neither vomited nor revealed any reduction in food consumption when exposed to provocative rotation. Other samples of monkeys known to be refractory to horizontal rotation and to sinusoidal vertical motion also exhibited little tendency to acquire a conditioned aversion to banana. But monkeys who had sham operations and those who revealed weak-to-strong signs of motion sickness exhibited a marked CFA (significant reduction in food intake). The strength of CFA was much greater when elicited in the test vehicle when compared with response in the home cage. The findings are interpreted as support for a limited application of CFA procedures for inferring the presence of motion-induced nausea and malaise.
C R Wilpizeski; L D Lowry; S J Green; B D Smith; H Melnick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  97     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-01-20     Completed Date:  1988-01-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  IM; S    
Department of Otolaryngology, Thomas Jefferson University Medical College, Philadelphia, PA 19107.
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MeSH Terms
Avoidance Learning / physiology
Conditioning, Classical / physiology
Ear, Inner / physiopathology
Motion Sickness / physiopathology*
Rotation / adverse effects
Taste / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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