Document Detail

Subjecting acute ischemic stroke patients to continuous tube feeding and an intensive computerized protocol establishes tight glycemic control.
MedLine Citation:
PMID:  19472086     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Tight glycemic control (TGC) after ischemic stroke may improve clinical outcome but previous studies failed to establish TGC, principally because of postprandial glucose surges. The aim of the present study was to investigate if safe, effective and feasible TGC can be achieved with continuous tube feeding and a computerized treatment protocol. METHODS: We subjected ten acute ischemic stroke patients with admission hyperglycemia (glucose >7.0 mmol/l (126.0 mg/dl)) to continuous tube feeding and a computerized intensive protocol with insulin adjustments every 1-2 h. Two groups of regularly fed patients from a previous study with a similar design served as controls. These groups comprised hyperglycemic patients treated according to an intermediate protocol with insulin adjustments at standard intervals (N = 13), and normoglycemic controls treated according to standard care (N = 15). The primary outcome was the percentage of time within target (4.4-6.1 mmol/l (79.2-109.8 mg/dl)). Secondary outcome was the number of patients with hypoglycemic episodes (glucose <3.0 mmol/l (54.0 mg/dl)). RESULTS: Median time within target was 55% in the continuously fed intensive group compared to 19% in the regularly fed intermediate group, and 58% in normoglycemic controls. Hypoglycemic episodes occurred in 20% of patients in the continuously fed group-lowest glucose level 2.4 mmol/l (43.2 mg/dl). In contrast, in the regularly fed group, this was 31%-lowest glucose level 1.6 mmol/l (28.8 mg/dl). CONCLUSIONS: TGC after acute ischemic stroke is feasible with continuous tube feeding and a computerized intensive treatment protocol. Although glycemic control is associated with hypoglycemia, no severe hypoglycemia occurred in the continuous tube feeding group.
N D Kruyt; G J Biessels; T M Vriesendorp; J H Devries; J B L Hoekstra; P W Elbers; L J Kappelle; P Portegies; M Vermeulen; Y B W E M Roos
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Publication Detail:
Type:  Journal Article     Date:  2009-05-27
Journal Detail:
Title:  Neurocritical care     Volume:  12     ISSN:  1556-0961     ISO Abbreviation:  Neurocrit Care     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Department of Neurology, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, the Netherlands.
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MeSH Terms
Acute Disease
Aged, 80 and over
Blood Glucose / metabolism*
Cerebral Infarction / blood,  therapy*
Cohort Studies
Critical Pathways*
Enteral Nutrition*
Feasibility Studies
Hyperglycemia / blood,  therapy*
Hypoglycemia / blood
Intensive Care*
Middle Aged
Therapy, Computer-Assisted*
Reg. No./Substance:
0/Blood Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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