| Subject-Specific Estimation of Central Aortic Blood Pressure Using an Individualized Transfer Function: A Preliminary Feasibility Study. | |
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MedLine Citation:
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PMID: 22147332 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This paper presents a new approach to the estimation of unknown central aortic blood pressure waveform from a directly measured peripheral blood pressure waveform, in which a physics-based model is employed to solve for a subject- and state-specific Individualized Transfer Function (ITF). The ITF provides the means to estimate the unknown central aortic blood pressure from the peripheral blood pressure. Initial proof-ofprinciple for the ITF is demonstrated experimentally through an in vivo protocol. In swine subjects taken through wide-ranging physiologic conditions, the ITF was on average able to provide central aortic blood pressure waveforms more accurately than a non-individualized transfer function. Its usefulness was most evident when the subjects pulse transit time deviated from normative values. In these circumstances, the ITF yielded statistically significant reductions over a non-individualized transfer function in the following three parameters: (i) 30% reduction in the root-mean-squared error between estimated versus actual central aortic blood pressure waveform (p<10-4), (ii) > 50% reduction in the error between estimated versus actual systolic and pulse pressures (p<10-4), and (iii) a reduction in the overall breakdown rate (i.e., the frequency of estimation errors > 3mmHg, p<10-4). In conclusion, the ITF may offer an attractive alternative to existing methods that estimate the central aortic blood pressure waveform, and may be particularly useful in non-normative physiologic conditions. |
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Authors:
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J-O Hahn; A T Reisner; F A Jaffer; H H Asada |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-29 |
Journal Detail:
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Title: IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society Volume: - ISSN: 1558-0032 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9712259 Medline TA: IEEE Trans Inf Technol Biomed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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