| Subglottic and Tracheal Stenosis due to Wegener's Granulomatosis. | |
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MedLine Citation:
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PMID: 22826070 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Wegener's granulomatosis (WG) is characterized histologically by necrotizing granulomatous angitis that most commonly involves the upper, lower respiratory tract and kidneys, but may affect any organ system. Otolaryngological manifestations are frequent and diverse but subglottic stenosis and tracheal stenosis are less common. The aim of the study was to assess the clinical features and the response to treatment in WG patients with subglottic or tracheal stenosis. The disease activity at the time of examination was scored in 55 patients with WG (29 females, 26 males) according to clinical, serological, radiological and bronchoscopic findings: subglottic and tracheal stenosis were observed in 9% and 5% of WG patients, respectively. CT scans of the larynx and trachea showed mucosal thickening extended 3-4 cm below the vocal cords in three and the thyroid cartilage in one patient. The degree of narrowing of the axial luminal diameter ranged 50-90%. Mechanical dilation of the stenosis and long-acting local corticosteroids may be of therapeutic benefit, along with conventional immunosuppressive treatment. |
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Authors:
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K Zycinska; K Wardyn; T M Zielonka; A Nitsch-Osuch; S Zarzycki; U Demkow; W Lukas; I Pirogowicz |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 755 ISSN: 0065-2598 ISO Abbreviation: - Publication Date: 2013 |
Date Detail:
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Created Date: 2012-7-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: - |
Other Details:
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Languages: ENG Pagination: 221-224 Citation Subset: - |
Affiliation:
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Department of Family Medicine, Internal and Metabolic Diseases Warsaw Medical University, Banacha 1a st, 02-097, Warsaw, Poland, kzycinska@poczta.fm. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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