| Subfield-specific loss of hippocampal N-acetyl aspartate in temporal lobe epilepsy. | |
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MedLine Citation:
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PMID: 17822430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: In patients with mesial temporal lobe epilepsy (MTLE) it remains an unresolved issue whether the interictal decrease in N-acetyl aspartate (NAA) detected by proton magnetic resonance spectroscopy ((1)H-MRS) reflects the epilepsy-associated loss of hippocampal pyramidal neurons or metabolic dysfunction. METHODS: To address this problem, we applied high-resolution (1)H-MRS at 14.1 Tesla to measure metabolite concentrations in ex vivo tissue slices from three hippocampal subfields (CA1, CA3, dentate gyrus) as well as from the parahippocampal region of 12 patients with MTLE. RESULTS: In contrast to four patients with lesion-caused MTLE, we found a large variance of NAA concentrations in the individual hippocampal regions of patients with Ammon's horn sclerosis (AHS). Specifically, in subfield CA3 of AHS patients despite of a moderate preservation of neuronal cell densities the concentration of NAA was significantly lowered, while the concentrations of lactate, glucose, and succinate were elevated. We suggest that these subfield-specific alterations of metabolite concentrations in AHS are very likely caused by impairment of mitochondrial function and not related to neuronal cell loss. CONCLUSIONS: A subfield-specific impairment of energy metabolism is the probable cause for lowered NAA concentrations in sclerotic hippocampi of MTLE patients. |
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Authors:
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Stefan Vielhaber; Heiko G Niessen; Grazyna Debska-Vielhaber; Alexei P Kudin; Jörg Wellmer; Jörn Kaufmann; Mircea Ariel Schönfeld; Robert Fendrich; Wieland Willker; Dieter Leibfritz; Johannes Schramm; Christian E Elger; Hans-Jochen Heinze; Wolfram S Kunz |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-05 |
Journal Detail:
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Title: Epilepsia Volume: 49 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-10 Completed Date: 2008-02-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 40-50 Citation Subset: IM |
Affiliation:
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Department of Neurology II, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aconitate Hydratase
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analysis Adult Aged Aspartic Acid / analogs & derivatives*, analysis, metabolism Cell Count Electroencephalography / statistics & numerical data Epilepsy, Temporal Lobe / metabolism*, pathology, surgery Female Glucose / analysis, metabolism Hippocampus / chemistry*, metabolism, pathology Humans Lactates / analysis, metabolism Magnetic Resonance Imaging / statistics & numerical data Magnetic Resonance Spectroscopy / statistics & numerical data Male Middle Aged Mitochondria / enzymology Mitochondrial Diseases / metabolism, pathology Parahippocampal Gyrus / chemistry, metabolism, pathology Preoperative Care Pyramidal Cells / chemistry, metabolism, pathology Sclerosis Succinates / analysis, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Succinates; 50-99-7/Glucose; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate; EC 4.2.1.3/Aconitate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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