Document Detail

Subfield-specific loss of hippocampal N-acetyl aspartate in temporal lobe epilepsy.
MedLine Citation:
PMID:  17822430     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In patients with mesial temporal lobe epilepsy (MTLE) it remains an unresolved issue whether the interictal decrease in N-acetyl aspartate (NAA) detected by proton magnetic resonance spectroscopy ((1)H-MRS) reflects the epilepsy-associated loss of hippocampal pyramidal neurons or metabolic dysfunction. METHODS: To address this problem, we applied high-resolution (1)H-MRS at 14.1 Tesla to measure metabolite concentrations in ex vivo tissue slices from three hippocampal subfields (CA1, CA3, dentate gyrus) as well as from the parahippocampal region of 12 patients with MTLE. RESULTS: In contrast to four patients with lesion-caused MTLE, we found a large variance of NAA concentrations in the individual hippocampal regions of patients with Ammon's horn sclerosis (AHS). Specifically, in subfield CA3 of AHS patients despite of a moderate preservation of neuronal cell densities the concentration of NAA was significantly lowered, while the concentrations of lactate, glucose, and succinate were elevated. We suggest that these subfield-specific alterations of metabolite concentrations in AHS are very likely caused by impairment of mitochondrial function and not related to neuronal cell loss. CONCLUSIONS: A subfield-specific impairment of energy metabolism is the probable cause for lowered NAA concentrations in sclerotic hippocampi of MTLE patients.
Stefan Vielhaber; Heiko G Niessen; Grazyna Debska-Vielhaber; Alexei P Kudin; Jörg Wellmer; Jörn Kaufmann; Mircea Ariel Schönfeld; Robert Fendrich; Wieland Willker; Dieter Leibfritz; Johannes Schramm; Christian E Elger; Hans-Jochen Heinze; Wolfram S Kunz
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-05
Journal Detail:
Title:  Epilepsia     Volume:  49     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-10     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-50     Citation Subset:  IM    
Department of Neurology II, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
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MeSH Terms
Aconitate Hydratase / analysis
Aspartic Acid / analogs & derivatives*,  analysis,  metabolism
Cell Count
Electroencephalography / statistics & numerical data
Epilepsy, Temporal Lobe / metabolism*,  pathology,  surgery
Glucose / analysis,  metabolism
Hippocampus / chemistry*,  metabolism,  pathology
Lactates / analysis,  metabolism
Magnetic Resonance Imaging / statistics & numerical data
Magnetic Resonance Spectroscopy / statistics & numerical data
Middle Aged
Mitochondria / enzymology
Mitochondrial Diseases / metabolism,  pathology
Parahippocampal Gyrus / chemistry,  metabolism,  pathology
Preoperative Care
Pyramidal Cells / chemistry,  metabolism,  pathology
Succinates / analysis,  metabolism
Reg. No./Substance:
0/Lactates; 0/Succinates; 50-99-7/Glucose; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate; EC Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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