| Subepithelial tissue pH of rat gastric mucosa exposed to luminal acid, barrier breaking agents, and hemorrhagic shock. | |
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MedLine Citation:
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PMID: 3338638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tissue pH in the immediate subepithelial layer of rat gastric mucosa was measured using H+-selective microelectrodes. Exposure of the mucosa to luminal acid (50-150 mM) caused a significant acidification of the subepithelial tissue. Contrary to expectation, disruption of the mucosal barrier with taurocholate (10 mM), acetylsalicylic acid (10 mM), or ethanol (20% vol/vol) during acid (100 mM HCl) perfusion promoted no further acidification of the subepithelial tissue but rather caused an alkalinization of the primarily acidified subepithelial tissue. When hemorrhagic shock was induced during acid perfusion, a profound acidification of the subepithelial tissue occurred even though a much lower luminal acidity (10 mM HCl) was used. Also, taurocholate had no alkalinizing influence on subepithelial pH during hemorrhagic shock, but caused a rapidly progressing and irreversible drop of the subepithelial tissue pH. The findings suggest that in normal stomach with intact "mucosal barrier," H+ back-diffusion occurs during exposure to acid. However, disruption of the mucosal barrier seems to lead to alkali (HCO3-) efflux from the mucosa, which neutralizes the influxing H+, thus "masking" H+ back-diffusion and protecting the mucosa. Yet, when adequate supply of HCO3- to the mucosa is blocked during exposure to a barrier-breaking agent and acid, increased H+ back-diffusion becomes again "unmasked," leading to extensive acidification and ulceration of the mucosa. |
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Authors:
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T Kiviluoto; J Voipio; E Kivilaakso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 94 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-03-11 Completed Date: 1988-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 695-702 Citation Subset: AIM; IM |
Affiliation:
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Second Department of Surgery, Helsinki University Central Hospital, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspirin / pharmacology Epithelium / metabolism Ethanol / pharmacology Female Gastric Acid / metabolism* Gastric Mucosa / drug effects, metabolism* Hydrochloric Acid / metabolism Hydrogen-Ion Concentration* Male Permeability Pyloric Antrum / metabolism Rats Rats, Inbred Strains Shock, Hemorrhagic / metabolism |
| Chemical | |
Reg. No./Substance:
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50-78-2/Aspirin; 64-17-5/Ethanol; 7647-01-0/Hydrochloric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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