Document Detail


Subendocardial resection for ventricular tachycardia: predictors of surgical success.
MedLine Citation:
PMID:  6478565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We retrospectively evaluated the first 100 patients who underwent mapping-guided subendocardial resection (SER) at our hospital for drug-refractory sustained ventricular tachycardia caused by coronary artery disease. There were 91 survivors of surgery with 200 morphologically distinct types of ventricular tachycardia. Eighty-three patients (91%) were cured of ventricular tachycardia by SER alone (60 patients or 66%) or by SER in combination with antiarrhythmic drug therapy (23 patients or 25%) (mean follow-up, 28 +/- 19 months). There were four late sudden deaths and four patients continued to have rare episodes of spontaneous ventricular tachycardia after surgery despite receiving antiarrhythmic drugs. Factors associated with failure of SER alone to cure ventricular tachycardia were presence of disparate sites of ventricular tachycardia origin (greater than 5 cm between mapped sites of origin; 64% vs 30% failure rate) and presence of multiple morphologically distinct spontaneous tachycardias (47% vs 25% failure rate). A log-linear model of multivariate analysis identified disparate sites of origin of ventricular tachycardia and the absence of a discrete left ventricular aneurysm as the only independent variables associated with failure of surgery alone. Inferior wall site of origin (41% vs 12% failure) and right bundle branch block morphology of ventricular tachycardia (20% vs 7% failure) were also significantly associated with failure of surgery to cure ventricular tachycardia. Mapping-guided SER is a highly effective mode of treatment for drug-refractory ventricular tachycardia, despite the existence of subgroups of patients with higher-than-average surgical failure rates.
Authors:
J M Miller; M G Kienzle; A H Harken; M E Josephson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  70     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-11-15     Completed Date:  1984-11-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  624-31     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Cardiac Output
Cardiac Pacing, Artificial
Electrocardiography
Endocardium / surgery*
Female
Heart Ventricles / surgery*
Humans
Male
Middle Aged
Myocardial Infarction / complications
Postoperative Complications / etiology
Prognosis
Recurrence
Tachycardia / surgery*
Grant Support
ID/Acronym/Agency:
HL00361/HL/NHLBI NIH HHS; HL22315/HL/NHLBI NIH HHS; HL24278/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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