| Subendocardial ischemia without coronary artery disease: is elevated left ventricular end diastolic pressure the culprit? | |
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MedLine Citation:
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PMID: 15140345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim was to investigate the association between elevated left ventricular end diastolic pressure (LVEDP) and subendocardial ischemia. METHODS: A retrospective chart review was performed of 1846 consecutive patients admitted between January and September 2002 who had chest pain, stress testing and coronary angiography. RESULTS: 1592 patients were excluded due to a positive coronary angiogram for coronary artery disease (CAD), 254 patients had an angiogram compatible with non-significant CAD and an ejection fraction > 45%; of whom 210 (82.7%) had a positive stress test (study group) and the others 44 (17.3%) had a negative stress test (control group). The mean LVEDP value for the study group (11.8 +/- 6.1 mmHg) was significantly higher than the mean LVEDP value for the control group (7.8 +/- 4.6 mmHg) (p < 0.001). In addition, there were more people with abnormal LVEDP (>or= 12 mmHg) in the study group (n = 103, 49.05%) compared with the control group (n = 10, 22.73%) (p < 0.001). Furthermore, the results of logistic regression revealed that patients with abnormal LVEDP values were 11 times more likely to have had a positive stress test. CONCLUSIONS: There appears to be a positive association between elevated LVEDP and subendocardial ischemia that manifests as a positive stress test in patients without evidence of significant CAD. |
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Authors:
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Abdul-Karim Elhabyan; Bernardo J Reyes; Omar Hallak; Mike Broce; James G Rosencrance; B Daniel Lucas; Hamid Fazal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current medical research and opinion Volume: 20 ISSN: 0300-7995 ISO Abbreviation: Curr Med Res Opin Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-13 Completed Date: 2004-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: England |
Other Details:
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Languages: eng Pagination: 773-7 Citation Subset: IM |
Affiliation:
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CAMC Health Education and Research Institute, West Virginia University, Charleston Area Medical Center, Charleston, West Virginia 25304, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Chi-Square Distribution Coronary Angiography Diastole Exercise Test Female Heart Ventricles / physiopathology* Humans Logistic Models Male Middle Aged Myocardial Ischemia / physiopathology* Retrospective Studies |
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