Document Detail


Subendocardial infarction produces epicardial parasympathetic denervation in canine left ventricle.
MedLine Citation:
PMID:  2923244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty dogs underwent anterior descending coronary artery dissection with most having occlusion that was either maintained or reperfused. Study was performed 1-4 days later. Multiple electrodes placed in normal and ischemic zones were used to determine the depth of the epicardial rim overlying a subendocardial infarction. This was done by comparing voltage differential with respect to time (dV/dt) measurements of sequential bipolar electrograms along each needle. By this means, test sites with a rim were documented, and depths of epicardial biopsies for choline acetyltransferase were chosen. Epicardial effective refractory period (ERP) responses to vagal nerve stimulation were measured. In sham-operated controls, vagal stimulation prolonged ERP, and choline acetyltransferase activity was equivalent in all sites. In contrast, dogs with all durations of coronary occlusion and various thicknesses of subendocardial infarction had no significant prolongation of ERP limited to rim sites overlying the infarct during vagal nerve stimulation. Corresponding choline acetyltransferase activity was decreased in rim sites compared with remote areas. In addition, dogs given norepinephrine or physostigmine (to potentiate parasympathetic responses) did not demonstrate significant ERP prolongation with vagal stimulation. Infusion of acetylcholine into the distal ligated coronary artery produced dose-dependent prolongation of ERP in sites overlying the infarct. These data taken together support the hypothesis that subendocardial infarction, regardless of its homogeneity or thickness, produces parasympathetic denervation of the overlying epicardial rim.
Authors:
J B Martins; R Lewis; D Wendt; D D Lund; P G Schmid
Related Documents :
1065294 - Regional differences in lactate concentration in experimental myocardial infarction.
19543984 - Myocardial electrical activity does not affect myocardial electrical impedance measurem...
6532174 - Histamine modification of spontaneous rate and rhythm in infarcted canine ventricle.
21593444 - Long-term efficacy of deferasirox in preventing cardiovascular complications in the iro...
23553584 - Prognostic value of unrecognised myocardial infarction detected by late gadolinium-enha...
16966244 - The modern mythology of the left-handedness of alexander the great.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  256     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-12     Completed Date:  1989-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H859-66     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Iowa, Iowa City.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Coronary Vessels / physiology
Denervation*
Dogs
Endocardium / physiology*
Heart Conduction System / physiopathology*
Heart Ventricles / innervation
Infarction / physiopathology*
Parasympathetic Nervous System / physiopathology*
Reference Values
Grant Support
ID/Acronym/Agency:
HL-32295/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Basal metabolic energy requirements of polarized and depolarized arrest in rat heart.
Next Document:  Mutual interaction of vasoconstriction and endothelial damage in stenotic arteries.