Document Detail

Subcutaneous panniculitis-like T-cell lymphoma with overlapping clinicopathologic features of lupus erythematosus: coexistence of 2 entities?
MedLine Citation:
PMID:  19590424     Owner:  NLM     Status:  MEDLINE    
We observed 5 patients with subcutaneous panniculitis-like T-cell lymphoma (SPTCL) who were unusual, in that they also exhibited features of lupus erythematosus (LE). This observation is in keeping with a recent study that reported an increased rate of autoimmune disease, including systemic lupus erythematosus (SLE), among patients with SPTCL. In all cases, attributes indicating SPTCL included an infiltrate of lymphocytes with pleomorphic nuclei involving subcutaneous lobules exhibiting a cytotoxic T-cell (CD3/CD8/betaF1) immunophenotype. Additionally, a high proliferation rate and a monoclonal T-cell receptor-gamma gene rearrangement were observed in most cases. The manifestations of LE in these patients included a spectrum of clinical and histopathological abnormalities. Clinical manifestations of LE included, in some patients, morphologic evidence of lupus erythematosus panniculitis (LEP) with subcutaneous nodules that healed with lipoatrophy on the face. In addition, all the patients exhibited serologic and/or extracutaneous end-organ abnormalities seen in patients with SLE, with 2 patients having sufficient findings to meet American College of Rheumatology criteria for SLE. Histopathological evidence of LE included vacuolar change at the dermal-epidermal interface in 3 patients, 2 of whom also showed interstitial deposition of mucin in the reticular dermis. One of these patients also had findings of LEP in the subcutaneous lobules with clusters of CD20 B cells partially arranged within germinal centers. In 2 patients in which neither the epidermis nor dermis was available for review, histopathological features of LE included, in one patient, a few small clusters of CD123 plasmacytoid dendritic cells within the adipose tissue and, in the other patient, a positive direct immunofluorescence test (lupus band) on clinically uninvolved and lesional skin. Our study shows that some patients show overlap between SPTCL and LE. We suspect that these patients may suffer from both diseases concomitantly. Furthermore, patients with LE, particularly LEP, should be monitored for evolution into SPTCL with biopsy of any subcutaneous lesion that is not typical of LEP. Additionally, screening for cutaneous LE and SLE could be considered in patients with SPTCL.
Laura B Pincus; Philip E LeBoit; Timothy H McCalmont; Roberto Ricci; Carlo Buzio; Lindy P Fox; Fergus Oliver; Lorenzo Cerroni
Related Documents :
14601004 - Cerebral blood flow assessed by brain spect with 99mtc-hmpao utilising the acetazolamid...
9150074 - Thrombocytopenic purpura as initial manifestation of systemic lupus erythematosus.
15345914 - Clinical significance of anticardiolipin and anti-beta2-glycoprotein i antibodies.
21331754 - Soluble cd40 ligand and prolactin levels in migraine patients during interictal period.
18353554 - Fibroblast growth factor-2 levels are elevated in the cerebrospinal fluid of multiple s...
1371664 - Palliative intubation for dysphagia in patients with carcinoma of the esophagus.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  31     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-22     Completed Date:  2009-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  520-6     Citation Subset:  IM    
Departments of Dermatology and daggerPathology, University of California San Francisco, San Francisco, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Gene Rearrangement, T-Lymphocyte
Genes, T-Cell Receptor gamma
Lupus Erythematosus, Systemic / complications*,  immunology,  pathology
Lymphoma, T-Cell / complications*,  immunology,  pathology
Middle Aged
Panniculitis / complications*,  immunology,  pathology
Polymerase Chain Reaction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  CD1a and factor XIIIa immunohistochemistry in leprosy: a possible role of dendritic cells in the pat...
Next Document:  A case of extreme hemodynamic lability and hypocalcemia.