Document Detail


Subcutaneous methylnaltrexone to restore postoperative bowel function in a long-term opiate user.
MedLine Citation:
PMID:  20134275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: One of the most common undesired effects of analgesic opioid use and addiction is constipation. Numerous pharmacologic agents have been used to treat opioid-induced bowel hypomotility with limited success. Methylnaltrexone bromide (MNTX) selectively targets the peripheral adverse effects of opioids while preserving the central analgesic effects of opioid agonist treatment. CASE: While it is indicated for use in nonsurgical patients in the palliative care setting, here we report the use of MNTX for the alleviation of postoperative ileus in a heroin user with recurrent cervical cancer undergoing diverting colostomy and urinary conduit placement. CONCLUSIONS: Results suggest that MNTX may accelerate postoperative gastrointestinal recovery in opioid-dependent patients. Further studies are warranted to evaluate its role in the pharmacologic management of postoperative ileus.
Authors:
Andras Ladanyi; Sarah M Temkin; Jonathan Moss
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  20     ISSN:  1525-1438     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  308-10     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, The University of Chicago, Chicago, IL, USA.
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / adverse effects*
Female
Heroin Dependence / complications
Humans
Ileus / chemically induced,  drug therapy*
Injections, Subcutaneous
Middle Aged
Naltrexone / analogs & derivatives*,  therapeutic use
Narcotic Antagonists / therapeutic use*
Postoperative Complications / drug therapy*
Quaternary Ammonium Compounds / therapeutic use
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Narcotic Antagonists; 0/Quaternary Ammonium Compounds; 16590-41-3/Naltrexone; 83387-25-1/methylnaltrexone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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