Document Detail


Subcutaneous interstitial fluid pressure and arm volume in lymphoedema.
MedLine Citation:
PMID:  1459796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interstitial fluid pressures were measured by the wick in needle method in the swollen and normal arms of 38 patients with lymphoedema resulting from treatment for breast cancer. The mean increase in arm volume, calculated from sequential circumferential measurements, was 33% (range 0.25 to 85.9). Subcutis interstitial fluid pressure in the swollen arm (2.0 cmH2O range -4.5 cmH2O to 6.8 cmH2O) was significantly greater (p < 0.001) than in the contralateral, non-swollen arm (-2.6 cmH2O range -11 cmH2O to 0 cmH2O). Interstitial fluid pressure in the oedematous arm did not correlate with the duration of the swelling (1-324 months), but did correlate with the increase in volume relative to the normal arm (r = 0.38, p < 0.05), the slope ('apparent compliance') being 28 ml.dl-1.cmH2O-1. The pressure-volume curve was less steep than the classic curve for acute oedema of dog limbs (Guyton, 1965). Vascular pressures were normal. The interstitial fluid pressures were not as high as those reported for lymphoedema of the lower extremity (mean 17.9 mmHg, Christensen et al., 1985). Nevertheless, the rise in interstitial fluid pressure by an average of 4.6 cmH2O constitutes a force opposing further microvascular fluid filtration and perhaps promoting fluid drainage out of the arm.
Authors:
D O Bates; J R Levick; P S Mortimer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  11     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-13     Completed Date:  1993-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  359-73     Citation Subset:  IM    
Affiliation:
Department of Physiological Medicine, St. George's Hospital Medical School, London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Arm
Blood Pressure / physiology
Breast Neoplasms / therapy
Connective Tissue / physiology*
Edema / physiopathology*
Extracellular Space / physiology*
Female
Humans
Lymphatic Diseases / etiology,  physiopathology*
Middle Aged
Pressure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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