| Subcutaneous injections of the tachykinin senktide reduce alcohol intake in alcohol-preferring rats. | |
| | |
MedLine Citation:
|
PMID: 7544465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study evaluated the effect of SC injections of the selective NK3 tachykinin agonist, Suc-[Asp6,MePhe8]substance P(6-11), also referred to as senktide (SENK), on 8% alcohol intake in genetically selected alcohol-preferring rats. Animals were offered access to 8% ethanol for 2 h/day (between 1800 and 2000 h) and to tap water for 4 h/day (between 1800 and 2200 h); SENK was injected 10 min before access to fluids. The peptide significantly reduced alcohol intake at doses of 125 and 250 micrograms/kg, but not at 62.5 micrograms/kg. The reduction in alcohol intake was accompanied by a sharp increase in water intake, so that total fluid intake was never significantly modified. The same SC doses of SENK did not modify water intake in rats with access to water, as the only fluid, for 4 h/day. In food-deprived rats food intake was not altered by 125 micrograms/kg, whereas 250 micrograms/kg produced a reduction in food intake that was smaller in intensity and shorter lasting than the reduction in alcohol intake. The same doses of SENK did not modify 0.1% saccharin intake, nor did they elicit major competing behaviors. The results of the present study are in keeping with those obtained following central injection of NK3 agonists, and show that a behaviorally selective reduction of alcohol intake can be evoked also by peripheral administration of SENK. |
| | |
Authors:
|
R Ciccocioppo; I Panocka; P Pompei; C Polidori; G de Caro; M Massi |
Related Documents
:
|
15691625 - Association of ambulatory blood pressure and dietary caffeine in adolescents. 1409955 - Salt appetite induced by doca treatment or adrenalectomy in rats: analysis of ingestive... 10790445 - The effect of food simulants on enamel-composite bond strength. 1868375 - Supplementation of broiler drinking water with liquid ammonium polyphosphate. 22819735 - Delay discounting and intake of ready-to-eat and away-from-home foods in overweight and... 11932955 - Changes in spatial memory mediated by experimental variation in food supply do not affe... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Peptides Volume: 16 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1995 |
Date Detail:
|
Created Date: 1995-09-27 Completed Date: 1995-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 533-7 Citation Subset: IM |
Affiliation:
|
Institute of Pharmacology, Faculty of Pharmacy, University of Camerino, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcohol Drinking
/
drug therapy* Analysis of Variance Animals Choice Behavior / drug effects* Drinking Behavior / drug effects Feeding Behavior / drug effects Injections, Subcutaneous Male Motor Activity / drug effects Peptide Fragments / pharmacology* Rats Rats, Inbred Strains Saccharin / pharmacology Substance P / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Peptide Fragments; 106128-89-6/senktide; 33507-63-0/Substance P; 81-07-2/Saccharin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Caudal raphe-dorsal vagal complex peptidergic projections: role in gastric vagal control.
Next Document: Effect of ribonuclease A and deoxyribonuclease I on immunostaining of Ki-67 in fixed-embedded sectio...