Document Detail

Subcutaneous granuloma annulare and IgA-IgG2 deficiency.
MedLine Citation:
PMID:  9677736     Owner:  NLM     Status:  MEDLINE    
Subcutaneous granuloma annulare (SGA) is a benign granulomatous disease occurring in childhood, with lesions most commonly located about the elbow, knee and scalp. the etiology of SGA remains obscure. We present a typical case with SGA also showing laboratory findings of IgA and IgG2 deficiency. Histologic findings of the lesions on the scalp were characterized by multiple large foci of complete collagen degeneration with a peripheral pallsade of histiocytes; the foci of degeneration was edematous basophilic. In contrast to current literature, an abnormality in the cellular immune system was not found. However, immune defects (IgA and IgG2 deficiency) related to the humoral immune system were observed.
N Kütükçüler; S Tütüncüoğlu; D Yilmaz; T Akalin; G Kandiloğlu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  40     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    1998 Apr-Jun
Date Detail:
Created Date:  1998-08-20     Completed Date:  1998-08-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  TURKEY    
Other Details:
Languages:  eng     Pagination:  279-81     Citation Subset:  IM    
Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
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MeSH Terms
Child, Preschool
Granuloma Annulare / complications*,  pathology
IgA Deficiency / blood,  complications*
IgG Deficiency / blood,  complications*
Respiratory Tract Infections / etiology
Scalp / pathology

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