Document Detail


Subcutaneous gold nanorods [corrected] detection with diffusion reflection measurement.
MedLine Citation:
PMID:  23389735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability to quantitatively and noninvasively detect nanoparticles nearby the skin surface has important implications on their development as an in vivo cancer diagnostic tool. The diffusion reflection (DR) method is a simple, noninvasive imaging technique which has been proven useful for the investigation of the optical parameters of the tissue. A new method is presented for the measurements of gold nanorod (GNR) concentration in tissue-like phantoms, based on DR measurement and intense light absorption of GNR. Monte Carlo simulations and tissue-like phantom measurements of the reflected light intensity are presented. The ability to extract optical properties of phantoms and their GNR concentrations from DR measurements is demonstrated, followed by a discussion about the best mathematical model for light propagation in tissues, based on the diffusion theory.
Authors:
Dror Fixler; Rinat Ankri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  18     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-02-07     Completed Date:  2013-06-06     Revised Date:  2013-09-01    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61226     Citation Subset:  IM    
Affiliation:
Bar-Ilan University, Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Ramat-Gan 52900, Israel. Dror.Fixler@biu.ac.il
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line, Tumor
Contrast Media / chemistry*,  diagnostic use*
Gold
Humans
Metal Nanoparticles / chemistry*,  ultrastructure*
Mice
Mice, Nude
Models, Biological
Molecular Imaging / methods*
Monte Carlo Method
Nanotubes / chemistry*,  ultrastructure*
Optical Phenomena
Phantoms, Imaging
Skin Neoplasms / diagnosis*
Subcutaneous Tissue / pathology
Transplantation, Heterologous
Chemical
Reg. No./Substance:
0/Contrast Media; 7440-57-5/Gold
Comments/Corrections
Erratum In:
J Biomed Opt. 2013 Jul;18(7):079801

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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