| Subcutaneous glucose monitoring with GlucoDay: comparison of the results to those obtained with the endocrine artificial pancreas. | |
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MedLine Citation:
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PMID: 20687398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was undertaken to assess the accuracy of GlucoDay- a portable detector of subcutaneous glucose--by comparing the results to those obtained by Biostator an established and reliable method for continuous glucose measurement in whole blood. DESIGN: Subjects with type 1 diabetes (n:6), subjects with type 2 diabetes (n:6), and six healthy controls were studied for 24 hours; they consumed three main meals. The GlucoDay was connected to the subjects by inserting a microfibre probe into the periumbilical subcutaneous area, whilst the Biostator was inserted by a double-lumen catheter into an antecubital vein. A third catheter was inserted into a separate vein for blood withdrawal to measure glucose by the hexokinase method. RESULTS: The three methods (GlucoDay-Biostator-hexokinase) were equally accurate in measuring glucose levels (p = 0.233, Kruskall-Wallis test). The glucose measurements performed with GlucoDay and Biostator were significantly correlated with those performed with hexokinase (p < 0.001, r2 = 66.65% and p < 0.001, r2 = 64.4%, respectively, using simple regression analysis). CONCLUSIONS: Measurements of glucose fluctuations in the subcutaneous tissue with the GlucoDay were close to those in blood determined by the Biostator. GlucoDay is therefore a reliable method for continuous glucose monitoring and may prove useful for optimizating treatment in patients with type 1 or type 2 diabetes. |
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Authors:
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George Dimitriadis; Eleni Boutati; Athanasios E Raptis; Erifili Hatziagelaki; Panayota Mitrou; Vaia Lambadiari; Nikolaos Tountas; Theofanis Economopoulos; Sotirios A Raptis |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Hormones (Athens, Greece) Volume: 9 ISSN: 1109-3099 ISO Abbreviation: Hormones (Athens) Publication Date: 2010 Apr-Jun |
Date Detail:
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Created Date: 2010-08-06 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101142469 Medline TA: Hormones (Athens) Country: Greece |
Other Details:
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Languages: eng Pagination: 145-50 Citation Subset: IM |
Affiliation:
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2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon University General Hospital, GR-12462, Haidari, Greece. gdimi@ath.forthnet.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism* Diabetes Mellitus, Type 1 / blood, diagnosis* Diabetes Mellitus, Type 2 / blood, diagnosis* Equipment Design Hexokinase / metabolism Humans Middle Aged Monitoring, Ambulatory / instrumentation* Pancreas, Artificial* Predictive Value of Tests Regression Analysis Reproducibility of Results Subcutaneous Tissue / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; EC 2.7.1.1/Hexokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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