Document Detail


Subcutaneous glucose monitoring with GlucoDay: comparison of the results to those obtained with the endocrine artificial pancreas.
MedLine Citation:
PMID:  20687398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was undertaken to assess the accuracy of GlucoDay- a portable detector of subcutaneous glucose--by comparing the results to those obtained by Biostator an established and reliable method for continuous glucose measurement in whole blood. DESIGN: Subjects with type 1 diabetes (n:6), subjects with type 2 diabetes (n:6), and six healthy controls were studied for 24 hours; they consumed three main meals. The GlucoDay was connected to the subjects by inserting a microfibre probe into the periumbilical subcutaneous area, whilst the Biostator was inserted by a double-lumen catheter into an antecubital vein. A third catheter was inserted into a separate vein for blood withdrawal to measure glucose by the hexokinase method. RESULTS: The three methods (GlucoDay-Biostator-hexokinase) were equally accurate in measuring glucose levels (p = 0.233, Kruskall-Wallis test). The glucose measurements performed with GlucoDay and Biostator were significantly correlated with those performed with hexokinase (p < 0.001, r2 = 66.65% and p < 0.001, r2 = 64.4%, respectively, using simple regression analysis). CONCLUSIONS: Measurements of glucose fluctuations in the subcutaneous tissue with the GlucoDay were close to those in blood determined by the Biostator. GlucoDay is therefore a reliable method for continuous glucose monitoring and may prove useful for optimizating treatment in patients with type 1 or type 2 diabetes.
Authors:
George Dimitriadis; Eleni Boutati; Athanasios E Raptis; Erifili Hatziagelaki; Panayota Mitrou; Vaia Lambadiari; Nikolaos Tountas; Theofanis Economopoulos; Sotirios A Raptis
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  9     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Affiliation:
2nd Department of Internal Medicine, Research Institute and Diabetes Center, Athens University Medical School, Attikon University General Hospital, GR-12462, Haidari, Greece. gdimi@ath.forthnet.gr
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism*
Diabetes Mellitus, Type 1 / blood,  diagnosis*
Diabetes Mellitus, Type 2 / blood,  diagnosis*
Equipment Design
Hexokinase / metabolism
Humans
Middle Aged
Monitoring, Ambulatory / instrumentation*
Pancreas, Artificial*
Predictive Value of Tests
Regression Analysis
Reproducibility of Results
Subcutaneous Tissue / metabolism*
Chemical
Reg. No./Substance:
0/Blood Glucose; EC 2.7.1.1/Hexokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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