Document Detail

Subcutaneous gentamycin implant to reduce wound infections after loop-ileostomy closure: a randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  16228839     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: After loop-ileostomy closure subcutaneous wound infection is the most frequent postoperative complication. Implantation of local antibiotics has been shown to reduce the incidence of wound infection after different surgical procedures, therefore, a subcutaneous application of a gentamycin implant may also decrease infection rate after ileostomy-closure. METHODS: We conducted a randomized, double-blind, placebo-controlled trial to evaluate the effectiveness of a subcutaneous gentamycin-collagen implant to reduce wound infection after loop-ileostomy closure. Patients had the same perioperative treatment and standardized anastomotic and closure technique. A collagen sponge with gentamycin was used in the treatment group and an identical collagen implant without antibiotics was used in the placebo group. RESULTS: Eighty patients (40 per group) were included. There was no difference between the groups with respect to demographics or in the postoperative course. The total wound infection rate was 10 percent with no difference between the gentamycin (n=4) and the collagen group (n=4) (P = 1.0). CONCLUSION: Subcutaneous implantation of a gentamycin sponge yields no clinically relevant reduction of the wound infection rate after loop-ileostomy closure so that routine use is not recommended in this procedure.
O Haase; W Raue; B Böhm; H Neuss; M Scharfenberg; W Schwenk
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  48     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-23     Completed Date:  2006-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2025-31     Citation Subset:  IM    
Department of General, Visceral, Vascular and Thoracic Surgery, University Medicine Berlin, Berlin, Germany.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*
Antibiotic Prophylaxis
Double-Blind Method
Drug Implants
Gentamicins / administration & dosage*
Ileostomy / adverse effects*
Middle Aged
Surgical Wound Infection / etiology,  prevention & control*
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Drug Implants; 0/Gentamicins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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