Document Detail

Subcutaneous fat necrosis of the newborn: light, ultrastructural and histochemical microscopic studies.
MedLine Citation:
PMID:  2760293     Owner:  NLM     Status:  MEDLINE    
Multiple subcutaneous plaques and nodules appeared on the back and the dorsal proximal area of the extremities of a 9-day-old male infant after a complicated prenatal period necessitating cesarean section. The clinical and histological features were diagnostic of subcutaneous fat necrosis of the newborn. Light microscopy revealed adipocyte necrosis, a lymphohistiocytic infiltrate, and needle-shaped clefts within adipocytes and macrophages. Ultrastructurally, there were aggregations of electron-lucent spaces in the form of spindles and needles arranged in parallel within the altered adipocytes; macrophages surrounded these cells or their fragments and invaded the fat lobules. Enzyme histochemical staining, not previously reported in the literature, showed that acid phosphatase, leucine aminopeptidase, and indoxyl and non-specific esterases were present in the areas of fat necrosis.
S J Friedman; R K Winkelmann
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  16     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-09-19     Completed Date:  1989-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Acid Phosphatase / metabolism
Adipose Tissue / metabolism,  pathology*,  ultrastructure
Carboxylic Ester Hydrolases / metabolism
Indoles / metabolism
Infant, Newborn
Infant, Newborn, Diseases / metabolism,  pathology*
Leucyl Aminopeptidase / metabolism
Microscopy, Electron
Skin Diseases / metabolism,  pathology
Reg. No./Substance:
0/Indoles; 480-93-3/indoxyl; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC; EC Phosphatase; EC Aminopeptidase

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