| Subcutaneous fat necrosis of the newborn: light, ultrastructural and histochemical microscopic studies. | |
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MedLine Citation:
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PMID: 2760293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple subcutaneous plaques and nodules appeared on the back and the dorsal proximal area of the extremities of a 9-day-old male infant after a complicated prenatal period necessitating cesarean section. The clinical and histological features were diagnostic of subcutaneous fat necrosis of the newborn. Light microscopy revealed adipocyte necrosis, a lymphohistiocytic infiltrate, and needle-shaped clefts within adipocytes and macrophages. Ultrastructurally, there were aggregations of electron-lucent spaces in the form of spindles and needles arranged in parallel within the altered adipocytes; macrophages surrounded these cells or their fragments and invaded the fat lobules. Enzyme histochemical staining, not previously reported in the literature, showed that acid phosphatase, leucine aminopeptidase, and indoxyl and non-specific esterases were present in the areas of fat necrosis. |
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Authors:
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S J Friedman; R K Winkelmann |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 16 ISSN: 0303-6987 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-09-19 Completed Date: 1989-09-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 99-105 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Mayo Clinic, Rochester, MN 55905. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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metabolism Adipose Tissue / metabolism, pathology*, ultrastructure Carboxylesterase Carboxylic Ester Hydrolases / metabolism Histocytochemistry Humans Indoles / metabolism Infant, Newborn Infant, Newborn, Diseases / metabolism, pathology* Leucyl Aminopeptidase / metabolism Male Microscopy, Electron Necrosis Skin Diseases / metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Indoles; 480-93-3/indoxyl; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.1/Carboxylesterase; EC 3.1.3.2/Acid Phosphatase; EC 3.4.11.1/Leucyl Aminopeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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