Document Detail

Subcutaneous fat necrosis associated with severe hypocalcaemia in a neonate.
MedLine Citation:
PMID:  16355105     Owner:  NLM     Status:  MEDLINE    
Subcutaneous fat necrosis (SFN) of the newborn is an uncommon disorder of the adipose tissue, mostly affecting full-term or post-term newborns who experience perinatal distress. The lesions of SFN typically occur during the first six weeks of life; they are usually self-limited and no specific therapy is required. The disorder may be rarely complicated with hypercalcaemia. We present the case of a neonate with perinatal asphyxia who manifested SFN followed by hypocalcaemia instead of hypercalcaemia and a biochemical profile of pseudohypoparathyroidism four weeks after the eruption of skin lesions. The infant was treated with alfacalcidiol. Blood biochemistry was normalized within one week and serum parathyroid hormone levels declined to normal over the next two months. It is suggested that perinatal asphyxia was the common etiopathogenetic factor for the development of both SFN and pseudohypoparathyroidism.
K Karochristou; T Siahanidou; T Kakourou-Tsivitanidou; K Stefanaki; H Mandyla
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  26     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-15     Completed Date:  2006-05-04     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  64-6     Citation Subset:  IM    
First Department of Pediatrics, Athens University, Aghia Sofia Childrens' Hospital, Athens, Greece.
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MeSH Terms
Asphyxia Neonatorum / complications*
Bone Density Conservation Agents / administration & dosage,  therapeutic use
Fat Necrosis / diagnosis,  drug therapy,  etiology*
Hydroxycholecalciferols / administration & dosage,  therapeutic use
Hypocalcemia / etiology*
Infant, Newborn
Parathyroid Hormone / blood
Pseudohypoparathyroidism / drug therapy,  etiology*
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Hydroxycholecalciferols; 0/Parathyroid Hormone; URQ2517572/alfacalcidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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