Document Detail

Subcutaneous cryptococcosis due to Cryptococcus diffluens in a patient with sporotrichoid lesions case report, features of the case isolate and in vitro antifungal susceptibilities.
MedLine Citation:
PMID:  17365654     Owner:  NLM     Status:  MEDLINE    
Environmental fungi, in particular primary pathogens and Cryptococcus spp. can be responsible for skin lesions mimicking sporotrichosis. In this paper, we report a case of subcutaneous cryptococcosis in an apparently healthy, young male patient due to a non-C. neoformans Cryptococcus species, C. diffluens. The isolate showed in vitro phenotypic switching that may affect virulence and host inflammatory and immune responses, and in vitro resistance to amphotericin B and 5-flucytosin. This species shares several phenotypic traits with C. neoformans, and, therefore, decisive diagnosis should be based on biopsy and culturing results followed by molecular identification.
A Serda Kantarcioğlu; Teun Boekhout; G Sybren De Hoog; Bart Theelen; Ayhan Yücel; Tuba R Ekmekci; Bettina C Fries; Reiko Ikeda; Adem Koslu; Kemal Altas
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical mycology     Volume:  45     ISSN:  1369-3786     ISO Abbreviation:  Med. Mycol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-09-04     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  173-81     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/DQ242643;  DQ242644
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MeSH Terms
Amphotericin B / pharmacology
Antifungal Agents / pharmacology
Base Sequence
Cryptococcosis / diagnosis,  microbiology*,  pathology
Cryptococcus / cytology,  drug effects*,  isolation & purification*,  physiology
DNA, Fungal / chemistry,  genetics
DNA, Ribosomal / chemistry,  genetics
DNA, Ribosomal Spacer / chemistry,  genetics
Diagnosis, Differential
Drug Resistance, Fungal
Flucytosine / pharmacology
Microbial Sensitivity Tests
Molecular Sequence Data
RNA, Ribosomal, 28S / genetics
Sequence Analysis, DNA
Sporotrichosis / diagnosis
Grant Support
Reg. No./Substance:
0/Antifungal Agents; 0/DNA, Fungal; 0/DNA, Ribosomal; 0/DNA, Ribosomal Spacer; 0/RNA, Ribosomal, 28S; 7XU7A7DROE/Amphotericin B; D83282DT06/Flucytosine

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