Document Detail


Subcutaneous Nerve Activity and Spontaneous Ventricular Arrhythmias in Ambulatory Dogs.
MedLine Citation:
PMID:  25460171     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Stellate ganglion nerve activity (SGNA) is important in ventricular arrhythmogenesis. However, because thoracotomy is needed to access the stellate ganglion, it is difficult to use SGNA for risk stratification.
OBJECTIVE: To test the hypothesis that subcutaneous nerve activity (SCNA) in canines can be used to estimate SGNA and predict ventricular arrhythmia.
METHODS: We implanted radio transmitters to continuously monitor left stellate ganglion and subcutaneous electrical activities in 7 ambulatory dogs with myocardial infarction, complete heart block and nerve growth factor infusion to the left stellate ganglion.
RESULTS: Spontaneous ventricular tachycardia (VT) or ventricular fibrillation (VF) was documented in each dog. SCNA preceded a combined 61 episodes of VT and VF, 61 frequent bigeminy or couplets and 61 premature ventricular contractions within 15 s in 70%, 59% and 61% of arrhythmias, respectively. Similar incidence of 75%, 69% and 62% was noted for SGNA. Progressive increase in SCNA (48.9 (95% CI 39.3-58.5) vs. 61.8 (95% CI 45.9-77.6) vs. 75.1 (95% CI 57.5-92.7) mV-s) and SGNA (48.6 (95% CI 40.9-56.3) vs. 58.5 (95% CI 47.5-69.4) vs. 69.0 (95% CI 53.8-84.2) mV-s) integrated over 20 s intervals was demonstrated 60 s, 40 s and 20 s prior to VT/VF (p<0.05). The Pearson's correlation coefficient for integrated SCNA and SGNA was 0.73±0.18 (p<0.0001 for all dogs, n=5). Both SCNA and SGNA exhibited circadian variation.
CONCLUSIONS: SCNA can be used as an estimate of SGNA to predict susceptibility to VT and VF in a canine model of ventricular arrhythmia and sudden cardiac death.
Authors:
Anisiia Doytchinova; Jheel Patel; Shengmei Zhou; Lan S Chen; Hongbo Lin; Changyu Shen; Thomas H Everett; Shien-Fong Lin; Peng-Sheng Chen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-7
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  -     ISSN:  1556-3871     ISO Abbreviation:  Heart Rhythm     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
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