Document Detail


Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates.
MedLine Citation:
PMID:  21727110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Therapeutic moderate hypothermia in newborns with hypoxic-ischemic encephalopathy is rapidly becoming standard clinical practice. We report here 12 cases of subcutaneous fat necrosis among 1239 cases registered with a national registry of newborns treated with moderate whole-body hypothermia. All the infants suffered from perinatal asphyxia and hypoxic-ischemic encephalopathy. Moderate-to-severe hypercalcemia was identified in 8 of 10 infants with blood calcium measurements. In all cases the skin lesions appeared after completion of the cooling treatment. Our data suggest that prolonged moderate hypothermia is an actual risk factor for subcutaneous fat necrosis. Because the lesions often develop several days after birth, physicians need to be aware of this condition as a possible complication in infants treated with moderate hypothermia after asphyxia. Blood calcium levels need to be monitored in affected infants.
Authors:
Brenda Strohm; Anna Hobson; Peter Brocklehurst; A David Edwards; Denis Azzopardi;
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-07-04
Journal Detail:
Title:  Pediatrics     Volume:  128     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-02     Completed Date:  2011-10-13     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e450-2     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Fat Necrosis / diagnosis*,  etiology*
Humans
Hypothermia, Induced / adverse effects*
Hypoxia-Ischemia, Brain / diagnosis,  therapy
Infant, Newborn
Subcutaneous Fat / pathology*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
G0100126//Medical Research Council; MC_U120081323//Medical Research Council
Investigator
Investigator/Affiliation:
M Thoresen / ; S Cherian / ; L Miall / ; M Chandrasekaran / ; A Quadri / ; M Kumar / ; T Austin / ; H O'Reilly / ; M Murphy / ; A Moore / ; D Azzopardi / ; N Tusor / ; G Pelligra /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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