| Subcutaneous Adipose Tissue Remodeling during the Initial Phase of Weight Gain Induced by Overfeeding in Humans. | |
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MedLine Citation:
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PMID: 22162470 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:Deciphering the early processes occurring in adipose tissue during weight gain is a major issue for understanding the development of fat mass and obesity. Experimental overfeeding in humans is a unique situation to tackle these events.Objective:Our aim was to identify the pathways involved in sc adipose tissue remodeling during the initial phase of weight gain.Research Design and Methods:Forty-four healthy men were involved in an overfeeding protocol with a lipid-enriched diet (+760 kcal/d) for 2 months. Subcutaneous abdominal adipose tissue biopsies were taken for histology, transcriptomics, and Western blotting in the basal state, after 14 d, and at the end of the protocol.Results:Overfeeding significantly increased body weight (+2.5 kg) and fat mass. Reorganization of gene expression patterns occurred in adipose tissue with an up-regulation of numerous genes involved in lipid metabolism and storage, followed by clusters of genes related to angiogenesis and extracellular matrix remodeling. Histological examination showed increased microvascular density and connective tissue deposition after 56 d of overfeeding, with no changes in the number of macrophages or inflammatory cells. Inhibition of the canonical Wnt/β-catenin signaling pathway and induction of the renin-angiotensin system might be implicated in the remodeling of sc adipose tissue.Conclusions:We characterize the coordinated and time-dependent processes that occur in human adipose tissue during the early phase of weight gain in healthy subjects and identify pathways representing potential targets in pathologies of adipose development, including obesity. |
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Authors:
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M Alligier; E Meugnier; C Debard; S Lambert-Porcheron; E Chanseaume; M Sothier; E Loizon; A Ait Hssain; J Brozek; J-Y Scoazec; B Morio; H Vidal; M Laville |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale Unit 1060 (M.A., E.M., C.D., E.L., H.V., M.L.), CarMeN Laboratory and Centre Européen Nutrition Santé, Lyon 1 University, F-69600 Oullins, France; Centre de Recherche en Nutrition Humaine (CRNH) Rhone-Alpes (M.A., S.L.-P., M.S., H.V., M.L.), Centre Hospitalier Lyon-Sud, F-69310 Pierre Bénite, France; Institut National de la Recherche Agronomique (INRA) Unit 1235 (E.M., H.V.), F-69600 Oullins, France; INRA (E.C., B.M.), Unité Mixte de Recherche 1019 Nutrition Humaine, CRNH Auvergne, Université Clermont, F-63000 Clermont-Ferrand, France; Service de Réanimation Médicale (A.A.H.), Hôpital Gabriel Montpied, F-63000 Clermont-Ferrand, France; Genfit (J.B.), F-59120 Loos, France; and Hospices Civils de Lyon (J.-Y.S.), Service d'Anatomopathologie, F-69008 Lyon, France. |
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