Document Detail

Subcortical nuclei volumetry in idiopathic generalized epilepsy.
MedLine Citation:
PMID:  16190937     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The exact anatomic and neurophysiologic correlates of idiopathic generalized epilepsy (IGE) in humans are still not well understood, although the thalamus has frequently been invoked as the crucial structure in the generation of primary generalized seizures. The few in vivo magnetic resonance (MR)-based studies in IGE patients suggest an altered cortical/subcortical gray matter ratio, but with no evidence of structural alterations of the thalamus. In this study, we sought to determine the volumes of the other subcortical structures. METHODS: The volumes of the caudate nucleus, putamen, pallidum as well as the thalamus were each determined in both hemispheres in 11 patients with various IGE syndromes, normalized for whole-brain volumes and then compared with 15 age-matched controls. RESULTS: No differences were noted in thalamic volumes, confirming previous reports. However, smaller subcortical volumes were noted in the IGE patients (p < 0.009), mainly due to smaller putamen bilaterally (p < or = 0.015). CONCLUSIONS: It is speculated that the presence of discrete frontal dysfunction, as noted in neuropsychological studies in IGE patients, indirectly supports our results because the putamen projects predominantly to the frontal cortex. Larger studies with more homogeneous patient populations are needed to determine the robustness of these findings and whether they are specific for particular IGE syndromes.
Margitta Seeck; Sylvain Dreifuss; Goran Lantz; Pierre Jallon; Giovanni Foletti; Paul-Andre Despland; Jacqueline Delavelle; Francois Lazeyras
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epilepsia     Volume:  46     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-29     Completed Date:  2005-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1642-5     Citation Subset:  IM    
Presurgical Epilepsy Evaluation Unit, Functional Neurology and Neurosurgery Program of the University Hospitals Lausanne and Geneva, Switzerland.
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MeSH Terms
Atrophy / pathology
Brain / pathology*
Caudate Nucleus / pathology
Cell Nucleus / pathology*
Cell Size
Epilepsy, Generalized / pathology*,  physiopathology
Frontal Lobe / physiopathology
Globus Pallidus / pathology
Karyometry / methods
Neurons / pathology*
Putamen / pathology
Thalamus / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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