| Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy. | |
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MedLine Citation:
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PMID: 10782769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Subcortical ischemic vascular dementia is associated with cortical hypometabolism and hypoperfusion, and this reduced cortical metabolism or blood flow can be detected with functional imaging such as positron emission tomography. The aim of this study was to characterize, by means of MR imaging and 1H MR spectroscopy, the structural and metabolic brain changes that occur among patients with subcortical ischemic vascular dementia compared with those of elderly control volunteers and patients with Alzheimer's disease. METHODS: Patients with dementia and lacunes (n = 11), cognitive impairment and lacunes (n = 14), and dementia without lacunes (n = 18) and healthy age-matched control volunteers (n = 20) underwent MR imaging and 1H MR spectroscopy. 1H MR spectroscopy data were coanalyzed with coregistered segmented MR images to account for atrophy and tissue composition. RESULTS: Compared with healthy control volunteers, patients with dementia and lacunes had 11.74% lower N-acetylaspartate/creatine ratios (NAA/Cr) (P = .007) and 10.25% lower N-acetylaspartate measurements (NAA) in the cerebral cortex (P = .03). In white matter, patients with dementia and lacunes showed a 10.56% NAA/Cr reduction (P = .01) and a 12.64% NAA reduction (P = .04) compared with control subjects. NAA in the frontal cortex was negatively correlated with the volume of white matter signal hyperintensity among patients with cognitive impairment and lacunes (P = .002). Patients with dementia, but not patients with dementia and lacunes, showed a 10.33% NAA/Cr decrease (P = .02) in the hippocampus compared with healthy control volunteers. CONCLUSION: Patients with dementia and lacunes have reduced NAA and NAA/Cr in both cortical and white matter regions. Cortical changes may result from cortical ischemia/infarction, retrograde or trans-synaptic injury (or both) secondary to subcortical neuronal loss, or concurrent Alzheimer's pathologic abnormalities. Cortical derangement may contribute to dementia among patients with subcortical infarction. |
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Authors:
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A A Capizzano; N Schuff; D L Amend; J L Tanabe; D Norman; A A Maudsley; W Jagust; H C Chui; G Fein; M R Segal; M W Weiner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 21 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-26 Completed Date: 2000-06-26 Revised Date: 2013-06-11 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 621-30 Citation Subset: IM |
Affiliation:
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Department of Veterans Affairs Medical Center, Magnetic Resonance Spectroscopy Unit, San Francisco, CA 94121, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aspartic Acid / analogs & derivatives, metabolism Brain Ischemia / complications, diagnosis*, metabolism* Creatine / metabolism Dementia, Vascular / complications, diagnosis*, metabolism* Female Humans Magnetic Resonance Imaging* Magnetic Resonance Spectroscopy / diagnostic use* Male |
| Grant Support | |
ID/Acronym/Agency:
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P01 AG012435-070002/AG/NIA NIH HHS; P01 AG012435-079001/AG/NIA NIH HHS; P01 AG12435/AG/NIA NIH HHS; R01 AG10897/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 57-00-1/Creatine; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
Comment In:
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AJNR Am J Neuroradiol. 2000 Apr;21(4):619-20
[PMID:
10782768
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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