Document Detail


Subconjunctival triamcinolone treatment for non-necrotising anterior scleritis.
MedLine Citation:
PMID:  20447959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To determine the outcome of treatment with subconjunctival triamcinolone acetate for non-necrotising anterior scleritis and to review the literature on this treatment. METHODS: A retrospective, interventional case series of 12 patients who had failed systemic therapy, treated with 25 subconjunctival triamcinolone for non-necrotising anterior scleritis. RESULTS: Complete resolution of symptoms and signs of scleral inflammation occurred after 23 out of the 25 injections administered. For the remaining two injections, it was necessary to increase oral corticosteroids to obtain complete resolution. No treated eye lost vision after subconjunctival triamcinolone therapy. No patient developed scleral necrosis after subconjunctival therapy. Four patients developed a rise in intraocular pressure after treatment. The mean follow-up was 9 months with a range of 1-20 months. Scleritis relapsed in 38% of eyes and required repeat subconjunctival triamcinolone therapy. CONCLUSION: This study provides evidence that subconjunctival triamcinolone therapy is an efficacious treatment with a prolonged duration of effect in selected patients with non-necrotising scleritis.
Authors:
A Roufas; B Jalaludin; C Gaskin; P McCluskey
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-05-06
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  94     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  743-7     Citation Subset:  IM    
Affiliation:
Save Sight Institute, University of Sydney and Sydney Eye Hospital, Sydney, NSW, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anterior Eye Segment
Anti-Inflammatory Agents / adverse effects,  therapeutic use*
Drug Evaluation
Epidemiologic Methods
Female
Glucocorticoids / administration & dosage,  therapeutic use*
Humans
Injections, Intraocular
Male
Middle Aged
Recurrence
Scleritis / drug therapy*
Treatment Outcome
Triamcinolone / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 124-94-7/Triamcinolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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