Document Detail

Subclinical thyrotoxicosis and the heart.
MedLine Citation:
PMID:  12165112     Owner:  NLM     Status:  MEDLINE    
Subclinical thyrotoxicosis is defined as a below normal thyrotropin (TSH) in association with a normal total and free thyroxine (T4) and triiodothyronine (T3). It may be caused by thyroid hormone treatment or by endogenous thyroid disease. The degree of thyrotoxicosis may be estimated by the level of TSH suppression. Subclinical thyrotoxicosis may be associated with changes in cardiac performance and morphology, but this has not been consistently found in all patient populations. Changes may include increased heart rate, increased left ventricular mass index, increased cardiac contractility, diastolic dysfunction, and the induction of ectopic atrial beats or arrhythmias. Cardiac exercise performance may be impaired. Subclinical thyrotoxicosis should be treated in patients with cardiac symptoms or disease. Treatment may include reduction of the thyroid hormone dose, treatment of the underlying thyroid condition, or beta-blockers.
Lynn A Burmeister; Angel Flores
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  12     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-08-07     Completed Date:  2003-01-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-9     Citation Subset:  IM    
Division of Endocrinology & Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Cardiomyopathies / diagnosis,  etiology*,  physiopathology
Cardiovascular Physiological Phenomena
Exercise Tolerance / drug effects,  physiology
Hemodynamics / drug effects,  physiology
Thyrotoxicosis / blood,  complications*,  therapy
Thyrotropin / blood
Thyroxine / therapeutic use
Ventricular Function, Left / physiology
Ventricular Premature Complexes / blood,  etiology,  physiopathology
Reg. No./Substance:
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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