Document Detail

Subclinical primary aldosteronism.
MedLine Citation:
PMID:  22863390     Owner:  NLM     Status:  In-Data-Review    
Screening for primary aldosteronism was historically recommended in patients with moderate to severe and/or resistant hypertension. Patients with mild hypertension and normotensive subjects were therefore excluded from the screening. However, a considerable number of normotensive individuals without hypokalaemia may have subclinical forms of primary aldosteronism. In this review, we describe evidence supporting the idea that primary aldosteronism is not only confined to patients with moderate to severe and/or resistant hypertension, but also exists in patients with mild hypertension and even in those with normotension. We discuss possible aetiologies, screening and diagnostic techniques and treatment options of the normotensive form of primary aldosteronism. The natural history, adverse effects and best treatment of this disease still remain to be resolved. The long-term follow-up studies of normotensive primary aldosteronism patients who receive neither adrenal surgery nor treatment with mineralocorticoid receptor antagonists might help to solve these problems.
Yuji Ito; Ryoyu Takeda; Yoshiyu Takeda
Publication Detail:
Type:  Journal Article     Date:  2012-05-22
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  26     ISSN:  1532-1908     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  485-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, KKR Hokuriku Hospital, Kanazawa, 2-13-43 Izumigaoka, Kanazawa, Ishikawa 921-8035, Japan.
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