Document Detail


Subclinical peripheral artery disease in patients undergoing peritoneal dialysis: risk factors and outcome.
MedLine Citation:
PMID:  19164255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Peripheral artery disease (PAD) is highly prevalent among patients in end-stage renal disease. The ankle-brachial index (ABI) is believed to be highly correlated with the subclinical PAD of lower extremities but little is known about the associated risk factors and outcome for PAD and ABI in patients on peritoneal dialysis (PD). METHODS: We performed a cohort study of 153 patients from a single center receiving stable PD for more than 3 months. These patients were screened for subclinical PAD using the ABI measurement. The ABI was measured and a ratio of <0.9 was considered abnormal. Clinical outcomes included actuarial patient and technique survival in this study. RESULTS: 30 patients were classified into a subclinical PAD group. The prevalence of PAD (subclinical and overt) in our PD center was 19.61% (30/153). Advanced age, preexisting diabetes, preexisting cardiovascular and/or cerebrovascular disease (CVD), lower renal Kt/V urea, lower renal creatinine clearance (WCrCl), lower serum albumin level, and higher serum triglyceride level were risk factors for PAD in our PD center. Bivariate analysis showed that ABI was positively correlated with residual renal Kt/V urea and WCrCl, but was not correlated with peritoneal Kt/V urea and WCrCl. Patient and technique survival rates were significantly lower in the low ABI group than in the normal ABI group. CONCLUSIONS: ABI is highly correlated with advanced age, preexisting diabetes, preexisting CVD, serum albumin, serum triglyceride, and residual renal clearance in PD patients. Also, lower ABI is independently associated with a high risk of patient mortality and PD technique failure.
Authors:
Jiung-Hsiun Liu; Hsin-Hung Lin; Ya-Fei Yang; Yao-Lung Liu; Huey-Liang Kuo; I-Kuan Wang; Che-Yi Chou; Chiu-Ching Huang
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  29     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  64-71     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology
Brachial Artery / physiopathology
Female
Follow-Up Studies
Humans
Intermittent Claudication / epidemiology,  etiology*,  physiopathology
Kidney Failure, Chronic / therapy
Male
Middle Aged
Peritoneal Dialysis / adverse effects*
Prevalence
Prognosis
Retrospective Studies
Risk Factors
Survival Rate / trends
Taiwan / epidemiology
Tibial Arteries / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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