| Subclinical peripheral arterial disease in rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 20553683 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis in the carotid arteries, but little is known about the magnitude of this process in peripheral arteries. Assessing preclinical atherosclerosis in both arterial beds in RA might provide additional prognostic value during risk stratification for primary prevention. Therefore in the present structural study we examined femoral versus carotid subclinical atherosclerosis in RA and controls. METHODS: Intima-media thickness (IMT) and atheromatous plaque presence and vulnerability in femoral versus carotid arteries were examined in 80 RA patients without overt cardiovascular disease or diabetes and 80 controls matched 1:1 for age, gender and traditional cardiovascular disease risk factors. RESULTS: Femoral IMT and plaque prevalence were increased in RA than controls (p=0.001 and 0.008, respectively). These increases remained significant after adjustment for potentially confounding factors that differed between groups, such as C-reactive protein and HDL-cholesterol serum levels, and statin use. Femoral plaque vulnerability did not differ between RA and controls. The presence of RA was found to be an independent predictor of increased femoral IMT (p=0.004), after adjustment for traditional cardiovascular risk factors, C-reactive protein and treatment with angiotensin converting enzyme inhibitors and statins. Femoral plaques were less frequent than carotid plaques in RA patients (22.5% vs 45.0% respectively, p=0.003) and in contrast to carotid plaques were independent of age and glucose levels. CONCLUSIONS: Subclinical peripheral atherosclerosis in RA is more advanced than in controls. Prospective studies are required to confirm that RA is an independent risk factor for peripheral arterial disease. |
| | |
Authors:
|
Kimon S Stamatelopoulos; George D Kitas; Christos M Papamichael; Katerina Kyrkou; Evangelia Zampeli; Kalliopi Fragiadaki; Vasileios F Panoulas; Myron Mavrikakis; Petros P Sfikakis |
Related Documents
:
|
6503253 - Recanalization of human arteries using nd-yag laser carried by optical fibre. 1386293 - Effect of balloon angioplasty on femoral artery evaluated with intravascular ultrasound... 712293 - Sympathetically induced atrial tachycardia. successful treatment by left stellate gangl... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-12 |
Journal Detail:
|
Title: Atherosclerosis Volume: 212 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-03 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 305-9 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, 80, Vassilissis Sofias Ave, PO Box 11528, Athens, Greece. stamatelopoulosk@yahoo.gr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use Arthritis, Rheumatoid / blood, epidemiology* Asymptomatic Diseases Atherosclerosis / blood, drug therapy, epidemiology*, ultrasonography Biological Markers / blood C-Reactive Protein / analysis Carotid Artery Diseases / blood, drug therapy, epidemiology*, ultrasonography Case-Control Studies Chi-Square Distribution Cholesterol, HDL / blood Female Femoral Artery* / ultrasonography Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Logistic Models Male Middle Aged Peripheral Arterial Disease / blood, drug therapy, epidemiology*, ultrasonography Prevalence Risk Assessment Risk Factors Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Biological Markers; 0/Cholesterol, HDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and...
Next Document: Symmetry indices based on accelerometric data in trotting horses.