Document Detail

Subclinical optic neuropathy in multiple sclerosis.
MedLine Citation:
PMID:  911226     Owner:  NLM     Status:  MEDLINE    
Optic neuropathy in multiple sclerosis is often not detectable by conventional clinical assessment. Temporal resolution of vision was measured at localized retinal sites by a simple perceptual test of double light-flash discrimination. Nine of 11 multiple sclerosis patients with normal fundi and no prior history of optic neuritis displayed abnormal temporal resolution. Double-flash discrimination was consistently more sensitive than any of the clinical variables measured and in some cases complementary to them. The more advanced the disease, the more spatially widespread was the double-flash impairment in the central visual field. There was a significantly increased level of double-flash impairment in advanced multiple sclerosis patients compared with patients with spinal forms of the disease and with unilateral retrobulbar neuritis.
R J Galvin; J R Heron; D Regan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  34     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  666-70     Citation Subset:  AIM; IM    
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MeSH Terms
Differential Threshold
Middle Aged
Multiple Sclerosis / complications*
Optic Neuritis / diagnosis*,  etiology,  physiopathology
Time Factors
Visual Fields

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