Document Detail

Subclinical inflammation during 3(rd) trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring.
MedLine Citation:
PMID:  24167021     Owner:  NLM     Status:  Publisher    
Objective: Growing evidence indicates that the metabolic syndrome (MS) is rooted in adverse exposures during fetal life. The aim of this study was to assess the possible associations between biomarkers of inflammation during 3rd trimester of pregnancy and markers of MS in adult offspring. Design and Methods: High sensitive C-reactive protein (CRP), tumor necrosis factor- (TNF-), interleukin-1 (IL-16) and interleukin-6 (IL-6) were measured in serum samples obtained in gestational week 30. Offspring were clinically examined at age 20 years. Analyses based on 439 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, pre-pregnancy body mass index (BMI), education, and offspring's sex. Offspring MS markers included waist circumference, BMI, blood pressure, HOMA insulin resistance (HOMA-IR) and plasma levels of fasting glucose, triglycerides, cholesterol fractions, insulin, and leptin. Results: The median level was 2.8 (interquartile range=3.3) µg/mL for CRP, for TNF-: 5.7 (3.2) pg/mL, for IL-1: 0.5 (0.4) pg/mL, and for IL-6: 1.1 (0.7) pg/mL. Concentrations were not significantly associated with MS markers in the offspring. The results remained essentially unchanged after correction for potential confounding. Conclusions: Markers for subclinical inflammation in 3(rd) trimester in healthy women were not associated with components of the metabolic syndrome in their adult offspring.
Inge Danielsen; Charlotta Granström; Dorte Rytter; Thorhallur I Halldorsson; Bodil Hammer Bech; Tine Brink Henriksen; Coen D A Stehouwer; Casper G Schalkwijk; Allan A Vaag; Sjurdur F Olsen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-25
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 The Obesity Society.
Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark; Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.
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