Document Detail

Subclinical infection with the nematode Trichostrongylus colubriformis increases gastrointestinal tract leucine metabolism and reduces availability of leucine for other tissues.
MedLine Citation:
PMID:  10709929     Owner:  NLM     Status:  MEDLINE    
Gastrointestinal (GI) tract leucine metabolism was measured in 6- to 9-mo-old lambs subjected to trickle infection with Trichostrongylus colubriformis larvae and in separate animals that were not infected. Animals prepared with a jejunal catheter and with indwelling catheters into the aorta and the portal- (PDV) and mesenteric- (MDV) drained viscera were infused simultaneously with [1-13C] and [5,5,5-2H3] leucine to determine GI tract sequestration of leucine from arterial and luminal amino acid pools by tracer and tracee arteriovenous concentration differences. Leucine oxidative losses and net fluxes were also determined across the GI tract. Infection had no detectable effect on whole-body leucine flux, but it increased total GI tract leucine sequestration by 24% (P<.05) and GI tract oxidative losses of leucine by 22 to 41% (P<.01). Net PDV fluxes of leucine were decreased by 20 to 32% during the infection. The infection did not alter either the proportion of precursor leucine used by GI tract metabolism that was derived from the arterial leucine pool (.84 to .88) or the proportional sequestration of digesta-derived leucine during "first pass" absorptive metabolism (.12 to .18). These findings help to elucidate the metabolic basis for the reduced growth rates and nitrogen retention observed when animals are subjected to subclinical nematode infection.
F Yu; L A Bruce; A G Calder; E Milne; R L Coop; F Jackson; G W Horgan; J C MacRae
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal science     Volume:  78     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-13     Completed Date:  2000-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  380-90     Citation Subset:  IM    
Rowett Research Institute, Bucksburn, Aberdeen, Scotland, UK.
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MeSH Terms
Biological Availability
Digestive System / metabolism*
Leucine / pharmacokinetics*
Models, Biological
Sheep Diseases / metabolism*
Trichostrongylosis / metabolism,  veterinary*
Reg. No./Substance:

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