| Subclinical impairment of arterial mechanics in systemic lupus erythematosus identified by arterial waveform analysis. | |
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MedLine Citation:
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PMID: 17356882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Structural and functional changes in wall and endothelial components of arterial blood vessels underlie the accelerated vascular disease progression in systemic lupus erythematosus (SLE). Using pulse contour analysis we sought to determine if subclinical vascular abnormalities could be identified in a well-characterised cohort of patients with SLE who had no increase in traditional cardiovascular risk factors. Radial artery pressure waveforms were obtained by applanation tonometry and pressure envelopes were analysed by descriptive and model-based approaches. Waveshape morphology was quantified by a novel eigenvector approach and model-based compliance indices of the large arteries (C1, capacitative arterial compliance) and small arteries (C2, reflective arterial compliance) were derived using a third-order four-element modified Windkessel model. Data were recorded from 30 patients with SLE (mean age 44 +/- 7 years and mean SLAM-R 10 +/- 4) and 19 age-matched control subjects. Significant differences in the lower frequency sinusoidal components of the pressure waveforms were evident between groups (P < 0.05). Both C1 and C2 were significantly reduced in patients with SLE: C1 mean +/- SD 13.5 +/- 4.0 ml/mmHg x 10 versus C1 17.5 +/- 4.8 ml/mmHg x 10 (P = 0.003 in patients vs. controls, respectively) and C2 5.2 +/- 3.4 ml/mmHg x 100 versus C2 9.4 +/- 2.8 ml/mmHg x 100 (P < 0.001 in patients vs. controls, respectively). In this group of SLE patients, without an excess of traditional cardiovascular risk factors and SLAM-R scores indicating mild disease, descriptive and model-based analysis of arterial waveforms identified vascular abnormalities at a preclinical stage. |
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Authors:
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Stephen A Wright; Fiona M O'Prey; Derrick J Rea; Michelle McHenry; Dennis G Johnston; R Canice McGivern; Michael B Finch; Aubrey L Bell; Gary E McVeigh |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-14 |
Journal Detail:
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Title: Rheumatology international Volume: 27 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2008-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 961-8 Citation Subset: IM |
Affiliation:
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Department of Therapeutics and Pharmacology, Whitla Medical Building, Queens University Belfast, Belfast, Northern Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atherosclerosis / physiopathology Case-Control Studies Female Humans Lupus Erythematosus, Systemic / physiopathology* Male Manometry / methods Middle Aged Pulsatile Flow / physiology* Radial Artery / physiopathology* Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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