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Subclinical cerebellar dysfunction in patients with migraine: Evidence from eyeblink conditioning.
MedLine Citation:
PMID:  24567118     Owner:  NLM     Status:  Publisher    
BACKGROUND: Clinical findings suggest cerebellar dysfunction in patients with migraine. Eyeblink classical conditioning (EBCC) is a simple form of associative learning which depends on the integrity of the cerebellum. The aim of this study was to assess whether EBCC is disturbed in patients with migraine.
METHODS: A delay conditioning paradigm was used in the headache-free interval in 32 female patients with migraine, in 24 of them without (MwoA) and eight with aura (MwA), and in 32 age-matched female controls. As primary outcome measure acquisition and as secondary outcome measures timing and extinction of conditioned eyeblink responses (CR) were assessed.
RESULTS: CR acquisition was significantly reduced in all migraine patients (mean total CR incidence 35.2 ± 22.1%) compared to controls (54.7 ± 21.3%; P  < 0.001; Bonferroni-corrected P level < 0.025) and in MwA patients (19.9 ± 20.2%) compared to matched controls (58.2 ± 27.0%; P  = 0.006) but not in MwoA patients (40.3 ± 20.6%) compared to matched controls (53.6 ± 19.7%; P  = 0.028; Bonferroni-corrected P level < 0.0166). Decrease of CR incidences in MwA patients was not significantly different compared to MwoA patients ( P  = 0.021; Bonferroni-corrected P level < 0.0166). CR timing and extinction was not affected in migraine patients.
CONCLUSIONS: Reduced acquisition of CRs in the cohort of female patients studied here supports findings of a cerebellar dysfunction in migraine.
Marcus Gerwig; Lisa Rauschen; Charly Gaul; Zaza Katsarava; Dagmar Timmann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-24
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  -     ISSN:  1468-2982     ISO Abbreviation:  Cephalalgia     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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