Document Detail

Subclinical celiac sprue. Increasing occurrence and clues to its diagnosis.
MedLine Citation:
PMID:  8421137     Owner:  NLM     Status:  MEDLINE    
We have reviewed the clinical records of 226 consecutive adult patients with celiac sprue diagnosed in our department from 1972 to 1989. The study period has been divided into three subperiods of 6 years each (1972-1977, 1978-1983, 1984-1989). From the first to the third subperiod a significant increase in the number of new diagnoses and of the proportion of patients recognized by minor symptoms has been observed. These patients represent 50% of our series in the last 3 years of the study and 70% in 1989. Diagnosing subclinical forms of celiac sprue has significantly lowered the mean age at diagnosis and the female/male ratio. First-degree relatives of celiac patients; subjects who had a gluten-free diet for a period during childhood; patients with short stature, anemia, or amenorrhea of no obvious cause; or patients with unexplained immunological abnormalities are the groups in which most patients with subclinical celiac sprue have been found and in which potential patients should be sought. Helpful diagnostic tools include antigliadin antibody testing and the observation of absent or reduced Kerckring folds in the descending duodenum in the course of upper gastrointestinal endoscopy.
G R Corazza; M Frisoni; E A Treggiari; R A Valentini; C Filipponi; U Volta; G Gasbarrini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  16     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-12     Completed Date:  1993-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  IM    
I Patologia Medica, Università di Bologna, Italy.
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MeSH Terms
Celiac Disease / diagnosis*,  epidemiology*
Italy / epidemiology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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