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Subclinical cardiac dysfunction in children with coeliac disease: is the gluten-free diet effective?
MedLine Citation:
PMID:  23209919     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Objectives. The aim of this study is to investigate the effects of coeliac disease on cardiac function in children using conventional transthoracic echocardiography (TTE) and tissue Doppler echocardiography (TDE). Methods. Coeliac disease patients were evaluated in two different groups based on serum endomysial antibody (EmA) titers (EmA (+) and EmA (-)), and the data obtained by conventional and TDE studies were compared between the patient groups and healthy controls. Results. There was no significant difference between EmA (+) and EmA (-) groups in terms of the conventional TTE parameters, including ejection fraction (EF), fractional shortening (FS), and left ventricle end diastolic diameter (LVEDD), that show the left ventricular systolic function (P = 0.727, P = 0.317, P = 0.118). TDE showed a significant difference in left ventricle (LV) isovolumic relaxation time (LV IVRT) and LV myocardial performance index (LV MPI) parameters between EmA (+) and EmA (-) patient groups (P < 0.0001). Conclusion. The measurement of LV MPI and LV IVRT parameters by TDE would be beneficial in early determination of the cardiac involvement and establishing appropriate treatment and followup of patients with coeliac disease as well as in making distinction between EmA (+) and EmA (-) patients.
Authors:
Berna Saylan; Ayhan Cevik; Ceyda Tuna Kirsaclioglu; Filiz Ekici; Ozgur Tosun; Gonca Ustundag
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Publication Detail:
Type:  Journal Article     Date:  2012-11-14
Journal Detail:
Title:  ISRN gastroenterology     Volume:  2012     ISSN:  2090-4401     ISO Abbreviation:  ISRN Gastroenterol     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-04     Completed Date:  2012-12-05     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  101563306     Medline TA:  ISRN Gastroenterol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  706937     Citation Subset:  -    
Affiliation:
Department of Pediatric Cardiology, Faculty of Medicine, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey.
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