Document Detail

Subclinical autonomic dysfunction in patients with Hodgkin's disease and non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  8217819     Owner:  NLM     Status:  MEDLINE    
A prospective study was carried out to determine the prevalence of autonomic dysfunction in patients with lymphoma, and to assess the effect on this of chemotherapy. Twenty consecutive patients presenting with Hodgkin's disease, high-grade non-Hodgkin's lymphoma, or low-grade non-Hodgkin's lymphoma were studied. All had advanced disease, requiring combination chemotherapy which included the use of vinca alkaloids. Clinical assessment and standard cardiovascular autonomic function tests were carried out prior to and following completion of chemotherapy. Although no patients had clinical evidence of autonomic neuropathy at presentation, 16 (80%) had abnormal cardiovascular autonomic function tests. There was no correlation with the presence or absence of mediastinal disease. There was significant improvement in autonomic scores with treatment despite the use of drugs of known neurological toxicity. Some patients showed residual abnormalities of autonomic function despite disease resolution. We suggest that subclinical autonomic dysfunction is common in patients with lymphoma, and probably represents a paraneoplastic syndrome--the pathogenesis and prevalence of which deserve further study. This phenomenon may predispose patients with lymphoma to develop gastrointestinal and genitourinary dysfunction, or postural hypotension, and should be considered during the evaluation of the neurotoxicity of chemotherapy regimens.
M L Turner; O M Boland; A C Parker; D J Ewing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  84     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-21     Completed Date:  1993-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  623-6     Citation Subset:  IM    
Department of Haematology, Royal Infirmary of Edinburgh, Scotland.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects,  therapeutic use
Autonomic Nervous System Diseases / etiology*
Heart / innervation
Hodgkin Disease / complications,  drug therapy
Lymphoma / complications*
Lymphoma, Non-Hodgkin / complications,  drug therapy
Paraneoplastic Syndromes / etiology
Prospective Studies

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