Document Detail


Subclinical audiological findings in carriers of recessive genes for deafness.
MedLine Citation:
PMID:  10529906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The existence of subclinical signs in the hearing of carriers of recessive mutations for deafness has aroused much controversy in the literature. The present study comprised 30 carriers of recessive mutations for deafness, and a control group of 30 healthy volunteers, matched for gender and age. All participants underwent a series of hearing tests, including pure-tone audiometry, speech tests, Bekesy audiometry and notch noise tests. The main results were: hearing loss in high frequencies (3000 and 4000 Hz), an elevation of the acoustic reflex threshold, as well as an elevation of the identification of 2000 Hz pure tone in the presence of white noise and notch noise. A notch in the Bekesy audiogram was also identified in several carriers. An interaction was found between gender and the carrier trait in the hearing threshold at 4000 Hz, and in the ipsi- and contralateral acoustic reflex at 500 Hz and 1000 Hz. These subclinical signs may be complementary to DNA research in the investigation of genetic deafness of unknown origin.
Authors:
M Berlin; C Legum; C Muchnik; M Hildesheimer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of basic and clinical physiology and pharmacology     Volume:  10     ISSN:  0792-6855     ISO Abbreviation:  J Basic Clin Physiol Pharmacol     Publication Date:  1999  
Date Detail:
Created Date:  1999-11-04     Completed Date:  1999-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9101750     Medline TA:  J Basic Clin Physiol Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  201-8     Citation Subset:  IM    
Affiliation:
Department of Communication Disorders, Sackler Faculty of Medicine, Tel Aviv University, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Deafness / diagnosis,  genetics*,  physiopathology
Genes, Recessive*
Hearing Tests
Heterozygote*
Humans
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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