| Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. | |
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MedLine Citation:
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PMID: 17420374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the relationship of subclinical atherosclerotic cardiovascular disease (CVD) and its risk factors with age-related macular degeneration (AMD) in the Multiethnic Study of Atherosclerosis. METHODS: This study included 6176 white, black, Hispanic, and Chinese participants aged 44 to 84 years from 6 communities in the United States. Measurements of subclinical CVD were performed according to standardized protocols. Fundus images were graded using the Wisconsin Age-Related Maculopathy Grading System. RESULTS: In analyses controlled for age, sex, race/ethnicity, and study location, early AMD was associated with a higher serum high-density lipoprotein cholesterol level (odds ratio per 15 mg/dL, 1.16; 95% confidence interval, 1.01-1.36) and the presence of echolucent carotid artery plaque (odds ratio for present vs no plaque, 0.37; 95% confidence interval, 0.18-0.74) in the whole cohort. Interactions of race/ethnicity and early AMD were found for carotid intima-media thickness, increasing severity of maximum carotid artery stenosis, serum triglyceride level, subclinical CVD severity, and Agatston calcium score. CONCLUSION: Few associations were found between subclinical CVD and CVD risk factors with early AMD. The findings of associations of early AMD with some signs of subclinical atherosclerotic CVD are different among the 4 racial/ethnic groups, which suggests that care must be taken in generalizing from one racial/ethnic group to another. |
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Authors:
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Ronald Klein; Barbara E K Klein; Michael D Knudtson; Mary Frances Cotch; Tien Yin Wong; Kiang Liu; Gregory L Burke; Mohammed F Saad; David R Jacobs; A Richey Sharrett |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of ophthalmology Volume: 125 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-10 Completed Date: 2007-05-03 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 534-43 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53726-2397, USA. kleinr@epi.ophth.wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group* Aged Aged, 80 and over Asian Continental Ancestry Group* Carotid Arteries / pathology Carotid Stenosis / pathology Cholesterol, HDL / blood Coronary Artery Disease / blood, ethnology* Ethnic Groups European Continental Ancestry Group* Female Hispanic Americans* Humans Macular Degeneration / blood, ethnology* Male Middle Aged Risk Factors Tunica Intima / pathology United States |
| Grant Support | |
ID/Acronym/Agency:
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HL69979-03/HL/NHLBI NIH HHS; M01-RR00645/RR/NCRR NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95166/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; Z01 EY000403-06/EY/NEI NIH HHS; Z01 EY000403-07/EY/NEI NIH HHS; Z99 EY999999/EY/NEI NIH HHS; ZIA EY000403-08/EY/NEI NIH HHS; ZIA EY000403-09/EY/NEI NIH HHS; ZIA EY000403-10/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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