Document Detail

Subclinical atherosclerosis and ambulatory blood pressure in children with metabolic syndrome.
MedLine Citation:
PMID:  24906664     Owner:  NLM     Status:  Publisher    
BACKGROUND: The metabolic syndrome (MS) has reached epidemic proportions worldwide. This syndrome is associated with cardiovascular risk factors, including functional and structural cardiac and vascular changes. The aim of our study was to evaluate subclinical atherosclerosis and its associated risk factors in children with MS.
METHODS: The study cohort comprised 52 children with MS and 38 age- and sex-matched healthy children. The diagnosis of MS was made according to criteria adopted by the World Health Organization. Blood pressure based on 24-h ambulatory blood pressure monitoring (ABPM), carotid intima-media thickness (cIMT), carotid distensibility coefficient (DC) and flow-mediated endothelium-dependent dilation (EDD) were assessed in all children.
RESULTS: We found a significantly higher cIMT in children with MS than in healthy children, but carotid DC and flow-mediated EDD were lower in the former. Multivariate analysis revealed that a higher cIMT was independently associated with a higher nighttime systolic blood pressure (SBP) and lower high-density lipoprotein-cholesterol (β = 0.386, p = 0.011 and β = 0.248, p = 0.042, respectively). Also, higher nighttime SBP remained an independent predictor of lower DC (β = 0.495, p = 0.009), and higher 24-h SBP was the only independent predictor for a lower EDD (β = 0.532, p = 0.004).
CONCLUSIONS: Atherosclerotic vascular changes were common among our pediatric patients with MS and easily determined by high-resolution ultrasound imaging. In particular, subclinical atherosclerosis was clearly associated with nocturnal or 24-h systolic hypertension as measured by ABPM. We therefore recommend that subclinical vascular changes and AMBP measurements should be used as diagnostic markers to predict atherosclerotic risks in this pediatric patient group.
Mahmut Civilibal; Nilgun Selcuk Duru; Murat Elevli
Related Documents :
7803634 - Bacteremia due to non-typhi salmonella: analysis of 64 cases and review.
19817264 - Efficacy and safety of saccharomyces boulardii in amebiasis-associated diarrhea in chil...
23409394 - Change in absolute cd4 count with antiretroviral treatment in resource limited setting:...
7677114 - Practice guidelines for ordering stool ova and parasite testing in a pediatric populati...
12595884 - Risks to children from exposure to lead in air during remedial or removal activities at...
9818254 - Recent advances in interventional pediatric cardiovascular disease.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-7
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  -     ISSN:  1432-198X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Subcutaneous omacetaxine mepesuccinate in patients with chronic myeloid leukemia in tyrosine kinase ...
Next Document:  Long-term, low-dose prophylaxis against urinary tract infections in young children.