Document Detail

Subclinical regional left ventricular dysfunction in obese patients with and without hypertension or hypertrophy.
MedLine Citation:
PMID:  20966911     Owner:  NLM     Status:  MEDLINE    
We investigated the impact of obesity on the abnormalities of systolic and diastolic regional left ventricular (LV) function in patients with or without hypertension or hypertrophy, and without heart failure. We studied 120 individuals divided into 6 groups of 20 patients (42 ± 6 years, 60 females) using standard and pulsed-wave tissue Doppler imaging (TDI) echocardiography, and heterogeneity index (HI): nonobese (I: no hypertension, no hypertrophy, control group; II: hypertension, no hypertrophy; III: hypertension and hypertrophy) and obese (IV: no hypertension, no hypertrophy; V: hypertension, no hypertrophy; VI: hypertension and hypertrophy). The criterion for obesity was BMI ≥30 kg/m2, for hypertension was blood pressure ≥ 140/90 mm Hg, for hypertrophy in nonobese was LV mass/body surface area (BSA) >134 g/m(2) (men) and >110 mg/m2 (women), and in obese was LV mass/height(2.7) >50 (men) and >40 (women). Obese groups had normal LV ejection fraction compared with nonobese groups, but decreased longitudinal and radial systolic myocardial peak velocities (S'), and early diastolic myocardial peak velocity (E'). Also, a great variability of E' and late diastolic myocardial peak velocity (A') from the longitudinal basal region was observed in obese groups (E'basal nonobese: 11 ± 7 vs. obese 19 ± 11, P < 0.001, A'basal nonobese: 7 ± 4 vs. obese 11 ± 7, P < 0.001). Our findings were more evident when comparing groups IV with V and VI, with the latter having concentric hypertrophy and obvious segmental systolic and diastolic dysfunctions. Subclinical myocardial alterations and increased variability of the velocities were observed in obese groups, especially with hypertension and hypertrophy, reflecting impaired regional LV relaxation, segmental atrial, and systolic dysfunctions.
José L F Santos; Vera M C Salemi; Michael H Picard; Charles Mady; Otávio R Coelho
Publication Detail:
Type:  Journal Article     Date:  2010-10-21
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  19     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-25     Completed Date:  2011-09-13     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1296-303     Citation Subset:  IM    
Faculdade de Ciências Médicas da Universidade Estadual de Campinas UNICAMP, São Paulo, Brazil.
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MeSH Terms
Body Mass Index
Body Surface Area
Cardiac Output
Early Diagnosis
Echocardiography, Doppler
Echocardiography, Doppler, Pulsed
Heart Ventricles / pathology,  ultrasonography
Hypertension / complications*,  physiopathology
Hypertrophy, Left Ventricular / complications*,  physiopathology
Middle Aged
Obesity / complications,  pathology,  physiopathology*
Organ Size
Prospective Studies
Reproducibility of Results
Severity of Illness Index
Ventricular Dysfunction, Left / etiology*,  pathology,  ultrasonography

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